Dorian M Cheff Selected Research

Neoplasms (Cancer)

1/2023	Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4.
1/2021	Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
12/2018	Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling.
1/2018	Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
10/2017	Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.
1/2017	A Drug of Such Damned Nature.1 Challenges and Opportunities in Translational Platinum Drug Research.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Dorian M Cheff Research Topics

Disease

6	Neoplasms (Cancer) 01/2023 - 01/2017
1	Inflammation (Inflammations) 12/2023
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2021
1	Glioma (Gliomas) 01/2021
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021
1	Neuroblastoma 12/2018
1	Carcinogenesis 01/2018
1	Pancreatic Neoplasms (Pancreatic Cancer) 11/2017
1	Sarcoma (Soft Tissue Sarcoma) 11/2017

Drug/Important Bio-Agent (IBA)

2	EnzymesIBA 01/2023 - 10/2017
2	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2021 - 10/2017
1	ArsenicIBA 12/2023
1	Protein Isoforms (Isoforms)IBA 01/2023
1	ChromatinIBA 12/2018
1	Glucose (Dextrose)FDA LinkGeneric 01/2018
1	Histone-Lysine N-MethyltransferaseIBA 01/2018
1	Proteins (Proteins, Gene)FDA Link 01/2018
1	Serine (L-Serine)FDA Link 01/2018
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2018
1	Lactic Acid (Lactate)FDA LinkGeneric 11/2017
1	alpha-hydroxyglutarateIBA 10/2017
1	PlatinumIBA 01/2017
1	DNA (Deoxyribonucleic Acid)IBA 01/2017

Therapy/Procedure

2	Therapeutics 10/2021 - 12/2018
1	Drug Therapy (Chemotherapy) 01/2023