Li Che Selected Research

Mitogen-Activated Protein Kinase Kinases (MEKs)

11/2019	MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment.
7/2019	Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma.
1/2018	Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model.

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Li Che Research Topics

Disease

28	Neoplasms (Cancer) 01/2023 - 12/2008
17	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 01/2016
9	Carcinogenesis 01/2021 - 01/2016
6	Breast Neoplasms (Breast Cancer) 11/2021 - 02/2011
6	Cholangiocarcinoma 10/2021 - 12/2017
4	Chronic Obstructive Pulmonary Disease (COPD) 01/2023 - 01/2021
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2022 - 01/2011
2	Inflammation (Inflammations) 01/2023 - 01/2022
2	Neuroblastoma 01/2021 - 03/2015
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2019 - 06/2014
2	Multiple Sclerosis 01/2019 - 06/2014
2	Liver Neoplasms (Liver Cancer) 01/2019 - 03/2015
2	Hepatoblastoma 01/2019 - 09/2017
2	Human Influenza (Influenza) 02/2011 - 07/2006
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 10/2023
1	Weight Loss (Weight Reduction) 10/2023
1	Diarrhea 10/2023
1	COVID-19 01/2022
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2022
1	Fatigue 01/2022
1	Necrosis 11/2019
1	Adenocarcinoma of Lung 06/2017
1	Lymphatic Metastasis 06/2017

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2008
6	Mechanistic Target of Rapamycin Complex 1IBA 11/2019 - 02/2016
5	Fatty Acid Synthases (Fatty Acid Synthase)IBA 01/2022 - 01/2016
5	TOR Serine-Threonine KinasesIBA 01/2020 - 09/2017
5	CateninsIBA 12/2019 - 11/2016
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 01/2016
4	Docetaxel (Taxotere)FDA Link 04/2013 - 02/2011
3	CytokinesIBA 01/2023 - 10/2013
3	Biomarkers (Surrogate Marker)IBA 06/2022 - 01/2022
3	MicroRNAs (MicroRNA)IBA 03/2022 - 12/2017
3	Mechanistic Target of Rapamycin Complex 2IBA 01/2020 - 12/2017
3	sapanisertibIBA 11/2019 - 12/2017
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2019 - 01/2018
2	ResistinIBA 01/2023 - 01/2021
2	cabozantinibIBA 01/2023 - 01/2021
2	Messenger RNA (mRNA)IBA 03/2022 - 12/2008
2	Interleukin-8 (Interleukin 8)IBA 01/2022 - 01/2021
2	Focal Adhesion Protein-Tyrosine KinasesIBA 10/2021 - 12/2018
2	Notch ReceptorsIBA 01/2021 - 03/2015
2	Phosphotransferases (Kinase)IBA 11/2019 - 12/2017
2	Peptides (Polypeptides)IBA 01/2019 - 06/2014
2	Small Interfering RNA (siRNA)IBA 01/2018 - 02/2016
2	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 01/2016
2	AntibodiesIBA 03/2015 - 06/2014
2	Thiotepa (Triethylenethiophosphoramide)FDA LinkGeneric 10/2013 - 02/2011
2	Capecitabine (Xeloda)FDA Link 07/2012 - 02/2011
1	Fluorouracil (Carac)FDA LinkGeneric 10/2023
1	G007-LKIBA 01/2023
1	TankyrasesIBA 01/2023
1	Toll-Like Receptor 4IBA 01/2023
1	SmokeIBA 01/2023
1	Genetic Markers (Genetic Marker)IBA 06/2022
1	6-methyladenineIBA 01/2022
1	chlorophyllin (copper chlorophyll)IBA 01/2022
1	ArtesunateIBA 01/2022
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2022
1	Methylnitronitrosoguanidine (MNNG)IBA 01/2022
1	Sincalide FDA Link 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	Verapamil (Calan)FDA LinkGeneric 01/2022
1	VitaminsIBA 01/2022
1	Interleukin-6 (Interleukin 6)IBA 01/2022
1	corylinIBA 11/2021
1	Tamoxifen FDA LinkGeneric 11/2021
1	Sirtuin 1IBA 11/2021
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 10/2021
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2021
1	Smad Proteins (Mothers Against Decapentaplegic Homolog)IBA 01/2021
1	CholesterolIBA 01/2020
1	Sirolimus (Rapamycin)FDA Link 11/2019
1	VimentinIBA 11/2019
1	Cadherins (E-Cadherin)IBA 11/2019
1	Oncogene Proteins (Oncogene Protein)IBA 10/2019
1	Ligases (Synthetase)IBA 10/2019
1	UbiquitinIBA 10/2019
1	Mitogen-Activated Protein KinasesIBA 07/2019
1	MTOR InhibitorsIBA 07/2019
1	TEA Domain Transcription FactorsIBA 01/2019
1	palbociclibIBA 01/2019
1	Monoclonal AntibodiesIBA 01/2019
1	Transcription Factor 4IBA 01/2019
1	Dasatinib (BMS 354825)FDA Link 12/2018
1	CarbohydratesIBA 01/2018
1	ElementsIBA 01/2018
1	Carrier Proteins (Binding Protein)IBA 01/2018
1	Cyclin-Dependent Kinase 6IBA 12/2017
1	Gemcitabine FDA Link 12/2017
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 12/2017
1	p38 Mitogen-Activated Protein KinasesIBA 06/2017
1	LipidsIBA 03/2017
1	Alanine (L-Alanine)FDA Link 01/2017
1	Peptide Initiation Factors (Initiation Factor)IBA 01/2017

Therapy/Procedure

7	Therapeutics 10/2021 - 10/2013
4	Drug Therapy (Chemotherapy) 01/2019 - 01/2011
3	Immunotherapy 06/2014 - 09/2012
1	Adjuvant Chemotherapy 10/2023
1	Injections 01/2019