Francis J Castellino Selected Research

Protein C Deficiency

1/2011	An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia.
10/2004	A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model.

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Francis J Castellino Research Topics

Disease

18	Infections 03/2024 - 08/2003
14	Inflammation (Inflammations) 03/2024 - 06/2005
12	Neoplasms (Cancer) 01/2014 - 05/2002
10	Sepsis (Septicemia) 03/2024 - 10/2004
7	Atherosclerosis 12/2021 - 05/2006
7	Wounds and Injuries (Trauma) 01/2021 - 08/2008
7	Thrombosis (Thrombus) 01/2019 - 09/2002
6	Endotoxemia 01/2015 - 03/2005
5	Hemorrhage 01/2019 - 10/2007
4	Fibrosis (Cirrhosis) 01/2017 - 08/2003
4	Adenoma (Adenomas) 07/2008 - 02/2003
3	Streptococcal Infections (Streptococcal Infection) 01/2022 - 01/2013
3	Brain Injuries (Brain Injury) 01/2015 - 02/2014
3	Infarction (Infarctions) 01/2015 - 03/2005
3	Carcinoma (Carcinomatosis) 01/2006 - 02/2003
3	Carcinogenesis 06/2004 - 02/2003
2	Cross Infection (Nosocomial Infection) 03/2024 - 09/2023
2	Urinary Tract Infections (Urinary Tract Infection) 03/2024 - 09/2023
2	Bacterial Infections (Bacterial Infection) 02/2024 - 01/2013
2	Hemolysis 01/2022 - 01/2016
2	Brain Ischemia (Cerebral Ischemia) 09/2020 - 12/2014
2	Ischemic Stroke 09/2020 - 01/2018
2	Tics (Tic) 06/2019 - 01/2016
2	Pneumonia (Pneumonitis) 02/2017 - 01/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2016 - 12/2014
2	Ischemia 01/2015 - 06/2004
2	Traumatic Brain Injuries (Traumatic Brain Injury) 05/2014 - 09/2011
2	Protein C Deficiency 01/2011 - 10/2004
2	Colonic Neoplasms (Colon Cancer) 01/2011 - 11/2003
2	Asthma (Bronchial Asthma) 02/2010 - 01/2007
2	Necrosis 02/2010 - 12/2006
2	Respiratory Hypersensitivity 05/2009 - 01/2007
2	Neoplasm Metastasis (Metastasis) 03/2009 - 05/2005
2	Nervous System Diseases (Neurological Disorders) 01/2009 - 05/2007
2	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 07/2008 - 11/2003
2	Peritonitis 10/2007 - 10/2004
2	Afibrinogenemia (Fibrinogen Deficiency) 05/2006 - 08/2005
1	Communicable Diseases (Infectious Diseases) 02/2024
1	Wound Infection (Wound Infections) 02/2024
1	Familial Primary Pulmonary Hypertension 01/2023
1	Vascular Remodeling 01/2023
1	Pulmonary Hypertension 01/2023
1	Hypoxia (Hypoxemia) 01/2023
1	COVID-19 01/2022
1	Periodontal Diseases (Periodontal Disease) 12/2021

Drug/Important Bio-Agent (IBA)

13	Protein CIBA 06/2019 - 10/2004
11	FibrinIBA 03/2024 - 08/2003
11	Proteins (Proteins, Gene)FDA Link 01/2023 - 08/2003
9	Fibrinogen (Factor I)FDA Link 03/2024 - 10/2004
9	PlasminogenIBA 12/2021 - 08/2003
8	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 09/2020 - 09/2006
7	Thrombin FDA Link 06/2019 - 08/2005
7	AnticoagulantsIBA 12/2011 - 06/2005
5	Plasminogen Activators (Plasminogen Activator)IBA 01/2017 - 03/2010
5	Adenosine Diphosphate (ADP)IBA 10/2014 - 01/2012
5	Endothelial Protein C ReceptorIBA 09/2010 - 09/2002
4	Plasminogen Activator Inhibitor 1IBA 01/2019 - 03/2010
4	Fibrinolysin FDA Link 01/2017 - 08/2003
3	streptolysin SIBA 01/2022 - 01/2016
3	Peptide Hydrolases (Proteases)FDA Link 01/2017 - 09/2010
3	CollagenIBA 01/2017 - 01/2007
3	Hemostatics (Antihemorrhagics)IBA 01/2016 - 08/2005
3	Thromboplastin (Tissue Factor)IBA 05/2014 - 05/2009
2	RNA (Ribonucleic Acid)IBA 01/2023 - 07/2008
2	oxidized low density lipoproteinIBA 12/2021 - 01/2018
2	IntegrinsIBA 01/2021 - 06/2010
2	Virulence Factors (Pathogenicity Factors)IBA 01/2021 - 01/2017
2	Glutamic Acid (Glutamate)FDA Link 09/2020 - 12/2014
2	Apolipoprotein B-48IBA 01/2018 - 05/2006
2	LDL CholesterolIBA 01/2018 - 05/2006
2	Apolipoprotein B-100 (Apo B 100)IBA 01/2018 - 05/2006
2	ApolipoproteinsIBA 01/2018 - 05/2006
2	LDL Receptors (LDL Receptor)IBA 01/2018 - 05/2006
2	AllergensIBA 02/2017 - 05/2009
2	Factor XII (Hageman Factor)IBA 02/2017 - 01/2017
2	Fibronectins (Fibronectin)IBA 01/2017 - 08/2003
2	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 01/2017 - 01/2013
2	CalciumIBA 01/2015 - 11/2003
2	Arachidonic Acid (Vitamin F)IBA 05/2014 - 05/2012
2	AngiostatinsIBA 01/2014 - 05/2002
2	Angiogenesis InhibitorsIBA 01/2014 - 05/2002
2	LipopolysaccharidesIBA 01/2011 - 03/2005
2	Sulindac (Copal)FDA LinkGeneric 01/2011 - 07/2008
2	Matrix Metalloproteinase 7 (Matrilysin)IBA 01/2011 - 07/2008
2	Factor X (Stuart Factor)IBA 05/2009 - 01/2007
2	MucinsIBA 05/2009 - 01/2007
2	CoagulantsIBA 03/2009 - 10/2004
2	Peptides (Polypeptides)IBA 10/2008 - 03/2005
2	Extracellular Matrix ProteinsIBA 08/2003 - 02/2003
1	Antimicrobial PeptidesIBA 02/2024
1	Anti-Bacterial Agents (Antibiotics)IBA 02/2024
1	Histones (Histone)IBA 01/2023
1	SphingolipidsIBA 01/2023
1	sphingosine kinaseIBA 01/2023
1	VaccinesIBA 01/2022
1	Chloride-Bicarbonate AntiportersIBA 01/2022
1	Sodium-Bicarbonate SymportersIBA 01/2022

Therapy/Procedure

7	Therapeutics 01/2022 - 08/2005
3	Resuscitation 06/2016 - 09/2011
2	Catheters 03/2024 - 09/2023