Peter C Butler Selected Research

Amyloid (Amyloid Fibrils)

1/2023	Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide.
1/2022	IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes.
1/2018	Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment.
4/2016	CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced β-Cell Apoptosis.
8/2014	Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity.
9/2010	The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity.
2/2010	Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway.
8/2009	Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat.
4/2009	Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.
5/2008	Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis.

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Peter C Butler Research Topics

Disease

48	Type 2 Diabetes Mellitus (MODY) 12/2023 - 01/2003
9	Insulin Resistance 01/2023 - 08/2003
6	Pancreatitis 07/2017 - 08/2006
5	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2020 - 08/2006
5	Hyperglycemia 01/2018 - 08/2003
5	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2016 - 05/2008
4	Amyloid Plaque 01/2019 - 09/2010
4	Alzheimer Disease (Alzheimer's Disease) 07/2015 - 02/2004
3	Chronic Pancreatitis 01/2018 - 05/2012
3	Proteostasis Deficiencies 11/2016 - 09/2010
3	Neoplasms (Cancer) 07/2013 - 07/2011
3	Hyperplasia 07/2013 - 07/2006
3	Pancreatic Neoplasms (Pancreatic Cancer) 07/2013 - 07/2011
2	Inflammation (Inflammations) 01/2018 - 07/2017
2	Parkinson Disease (Parkinson's Disease) 07/2015 - 11/2009
2	Neuroendocrine Tumors (Neuroendocrine Tumor) 10/2013 - 07/2013
2	Hypoglycemia (Reactive Hypoglycemia) 07/2013 - 07/2006
2	Metaplasia 05/2012 - 07/2009
2	Thyroid Neoplasms (Thyroid Cancer) 01/2012 - 07/2011
2	Disease Progression 11/2009 - 07/2009
1	Prediabetic State (Prediabetes) 01/2019
1	Cystic Fibrosis (Mucoviscidosis) 09/2018
1	Mitochondrial Diseases (Mitochondrial Disease) 11/2016
1	Dehydration (Water Stress) 01/2016
1	Brain Death (Brain Dead) 01/2016
1	Metabolic Diseases (Metabolic Disease) 04/2015
1	Weight Loss (Weight Reduction) 07/2013
1	Papillary Thyroid Cancer 01/2012
1	Papillary Carcinoma 01/2012
1	Retinoblastoma (Glioblastoma, Retinal) 08/2011
1	Infections 09/2008
1	Insulinoma 01/2008
1	Glucose Intolerance 08/2006
1	Morbid Obesity 07/2006
1	Genetic Predisposition to Disease (Genetic Predisposition) 02/2004
1	Diabetes Mellitus 08/2003

Drug/Important Bio-Agent (IBA)

30	Islet Amyloid PolypeptideIBA 12/2023 - 07/2003
21	Amyloid (Amyloid Fibrils)IBA 01/2023 - 07/2003
18	Insulin (Novolin)FDA Link 01/2023 - 08/2003
12	Proteins (Proteins, Gene)FDA Link 01/2023 - 06/2004
11	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2003
7	Hormones (Hormone)IBA 09/2018 - 11/2009
5	Glucagon (Glukagon)FDA Link 01/2018 - 04/2006
4	Glucagon-Like Peptide 1 (GLP 1)IBA 10/2016 - 01/2012
2	UbiquitinIBA 12/2023 - 01/2011
2	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2023 - 01/2011
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 11/2007
2	RNA (Ribonucleic Acid)IBA 01/2020 - 11/2018
2	CytokinesIBA 01/2020 - 01/2018
2	Chromogranin AIBA 09/2018 - 01/2018
2	IncretinsIBA 10/2013 - 07/2013
2	Peptides (Polypeptides)IBA 04/2013 - 07/2003
2	Glucagon-Like Peptide-1 ReceptorIBA 05/2012 - 01/2012
2	Exenatide (Byetta)FDA Link 05/2012 - 07/2011
2	Sitagliptin Phosphate (Januvia)FDA Link 07/2011 - 07/2009
2	Amyloidogenic ProteinsIBA 01/2010 - 05/2008
1	FructoseIBA 01/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2020
1	Phosphotransferases (Kinase)IBA 01/2020
1	Hypoxia-Inducible Factor 1IBA 01/2020
1	ChromograninsIBA 05/2017
1	CalpainIBA 11/2016
1	CCAAT-Enhancer-Binding ProteinsIBA 04/2016
1	Ethanol (Ethyl Alcohol)IBA 01/2016
1	AutoantibodiesIBA 01/2016
1	TolueneIBA 01/2016
1	Protein AggregatesIBA 07/2015
1	Insulysin (Insulin-Degrading Enzyme)IBA 08/2014
1	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 07/2013
1	Glucagon-Like Peptides (Enteroglucagon)IBA 05/2012
1	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 01/2012
1	E2F Transcription FactorsIBA 08/2011
1	HeterochromatinIBA 08/2011
1	Chromobox Protein Homolog 5IBA 08/2011
1	Small Interfering RNA (siRNA)IBA 04/2011
1	Cyclin-Dependent Kinase 5IBA 04/2011
1	CurcuminIBA 09/2010
1	CalciumIBA 01/2010
1	Peptide Hydrolases (Proteases)FDA Link 01/2010
1	alpha-SynucleinIBA 11/2009
1	Blood Glucose (Blood Sugar)IBA 07/2009
1	Metformin (Glucophage)FDA LinkGeneric 07/2009
1	TunicamycinIBA 01/2008
1	AntibodiesIBA 01/2008
1	IsotopesIBA 08/2006
1	AcidsIBA 06/2004
1	Amyloid beta-PeptidesIBA 02/2004

Therapy/Procedure

9	Therapeutics 07/2017 - 07/2011
3	Pancreatectomy 08/2006 - 07/2006
2	Islets of Langerhans Transplantation 01/2007 - 08/2006
1	Catheters 09/2008
1	Investigational Therapies (Experimental Therapy) 08/2006
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 07/2006