Martin Bushell Selected Research

Proteins (Proteins, Gene)

3/2024	Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis.
11/2021	Codon optimality in cancer.
1/2021	The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.
1/2021	MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression.
12/2019	mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity.
11/2017	Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf).
6/2017	Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
1/2016	Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition.
5/2012	Sustained translational repression by eIF2α-P mediates prion neurodegeneration.
10/2010	Translational regulation of gene expression during conditions of cell stress.

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Martin Bushell Research Topics

Disease

15	Neoplasms (Cancer) 01/2024 - 05/2010
8	Carcinogenesis 03/2024 - 01/2008
3	Genomic Instability 11/2023 - 03/2010
3	Obesity 01/2022 - 06/2014
3	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 01/2015
3	Hypoxia (Hypoxemia) 10/2010 - 01/2008
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2024 - 12/2010
2	Maternal Obesity 01/2024 - 01/2022
2	Ischemia 01/2024 - 01/2013
2	Mesothelioma 01/2021 - 11/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2017 - 05/2012
1	Leukemia 03/2024
1	Reperfusion Injury 01/2024
1	Adenocarcinoma 01/2023
1	Malignant Mesothelioma 01/2021
1	Prostatic Neoplasms (Prostate Cancer) 12/2020
1	Polyploidy 12/2020
1	Disease Progression 11/2017
1	Memory Disorders (Memory Loss) 06/2017
1	Glucose Intolerance 01/2016
1	Ependymoma 09/2015
1	Adenoma (Adenomas) 01/2015
1	Insulin Resistance 06/2014
1	Stroke (Strokes) 01/2013
1	Infarction (Infarctions) 01/2013
1	Neoplasm Metastasis (Metastasis) 06/2012
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 05/2012
1	Shock 10/2010
1	Infections 01/2010
1	Breast Neoplasms (Breast Cancer) 04/2002

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 03/2024 - 01/2008
7	MicroRNAs (MicroRNA)IBA 01/2024 - 07/2010
3	Mechanistic Target of Rapamycin Complex 1IBA 01/2021 - 01/2015
2	5' Untranslated Regions (5' UTR)IBA 01/2024 - 01/2010
2	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 12/2023 - 11/2023
2	DNA (Deoxyribonucleic Acid)IBA 12/2023 - 05/2009
2	Phosphotransferases (Kinase)IBA 01/2023 - 02/2011
2	AsbestosIBA 01/2021 - 11/2017
2	MTOR InhibitorsIBA 01/2021 - 01/2015
2	Eukaryotic Initiation Factor-4EIBA 01/2021 - 01/2010
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 06/2012
2	Transcription Factors (Transcription Factor)IBA 12/2018 - 05/2010
2	Insulin (Novolin)FDA Link 01/2016 - 06/2014
1	Ribosomal Proteins (Ribosomal Protein)IBA 03/2024
1	eIF-4BIBA 01/2024
1	GTP Phosphohydrolases (GTPases)IBA 01/2023
1	AMP-Activated Protein KinasesIBA 01/2023
1	LipidsIBA 01/2022
1	Transfer RNA (tRNA)IBA 11/2021
1	Codon (Codons)IBA 11/2021
1	Amino Acid Transport Systems (Amino Acid Transporter)IBA 01/2021
1	Glutamine (L-Glutamine)FDA Link 01/2021
1	Large Neutral Amino Acid-Transporter 1IBA 01/2021
1	AntiportersIBA 01/2021
1	Docetaxel (Taxotere)FDA Link 12/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Cyclin-Dependent Kinase Inhibitor p16IBA 11/2017
1	Carbon Fiber (Grafil)IBA 11/2017
1	Trazodone (Trittico)FDA LinkGeneric 06/2017
1	Eukaryotic Initiation Factor-2 (EIF 2)IBA 06/2017
1	dibenzoylmethaneIBA 06/2017
1	PrionsIBA 06/2017
1	PlatinumIBA 09/2015
1	Sirolimus (Rapamycin)FDA Link 01/2015
1	Messenger RNA (mRNA)IBA 07/2010
1	p38 Mitogen-Activated Protein KinasesIBA 03/2010
1	Viral ProteinsIBA 01/2010
1	ThapsigarginIBA 01/2010
1	Eukaryotic Initiation Factor-4G (Eukaryotic Initiation Factor 4G)IBA 01/2010
1	CaspasesIBA 04/2002
1	Caspase 3 (Caspase-3)IBA 04/2002
1	TNF-Related Apoptosis-Inducing LigandIBA 04/2002
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2002

Therapy/Procedure

5	Therapeutics 01/2021 - 05/2010
1	Drug Therapy (Chemotherapy) 12/2020