D Bonifacio Selected Research

Uterine Cervical Neoplasms (Cancer of the Cervix)

2/2007	Up-regulation of proliferating cell nuclear antigen (PCNA) is closely associated with high-risk human papillomavirus (HPV) and progression of cervical intraepithelial neoplasia (CIN), but does not predict disease outcome in cervical cancer.
11/2006	Upregulation of telomerase (hTERT) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papillomavirus, virus persistence, or disease outcome in cervical cancer.
10/2006	Down-regulated nucleoside diphosphate kinase nm23-H1 expression is unrelated to high-risk human papillomavirus but associated with progression of cervical intraepithelial neoplasia and unfavourable prognosis in cervical cancer.
8/2006	Upregulation of nuclear factor-kappaB (NF-kappaB) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papillomavirus or disease outcome in cervical cancer.
3/2006	Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are prognostic factors in cervical cancer, related to invasive disease but not to high-risk human papillomavirus (HPV) or virus persistence after treatment of CIN.
1/2006	Aberrant expression of VEGF-C is related to grade of cervical intraepithelial neoplasia (CIN) and high risk HPV, but does not predict virus clearance after treatment of CIN or prognosis of cervical cancer.
1/2006	Down-regulation of E-cadherin is closely associated with progression of cervical intraepithelial neoplasia (CIN), but not with high-risk human papillomavirus (HPV) or disease outcome in cervical cancer.

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D Bonifacio Research Topics

Disease

7	Uterine Cervical Neoplasms (Cancer of the Cervix) 02/2007 - 01/2006
6	Uterine Cervical Dysplasia 02/2007 - 01/2006
4	Neoplasms (Cancer) 11/2006 - 01/2006
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 08/2006 - 01/2006
2	Carcinogenesis 03/2006 - 01/2006
1	Neoplasm Metastasis (Metastasis) 03/2006

Drug/Important Bio-Agent (IBA)

2	Oncogene Proteins (Oncogene Protein)IBA 02/2007 - 11/2006
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 02/2007
1	Telomerase (Telomerase Reverse Transcriptase)IBA 11/2006
1	Nucleoside-Diphosphate KinaseIBA 10/2006
1	NF-kappa B (NF-kB)IBA 08/2006
1	Tissue Inhibitor of Metalloproteinase-2IBA 03/2006
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 03/2006
1	Matrix Metalloproteinases (MMPs)IBA 03/2006
1	Vascular Endothelial Growth Factor CIBA 01/2006
1	Cadherins (E-Cadherin)IBA 01/2006

Therapy/Procedure

3	Aftercare (After-Treatment) 11/2006 - 01/2006