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Bruce E Blough Selected Research

Methadone (Dolophine)

11/2022Effect of TRV130 and methadone on fentanyl-vs.-food choice and somatic withdrawal signs in opioid-dependent and post-opioid-dependent rats.
12/2020In a Rat Model of Opioid Maintenance, the G Protein-Biased Mu Opioid Receptor Agonist TRV130 Decreases Relapse to Oxycodone Seeking and Taking and Prevents Oxycodone-Induced Brain Hypoxia.

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Bruce E Blough Research Topics

Disease

18Cocaine-Related Disorders (Cocaine Addiction)
12/2016 - 06/2002
7Substance-Related Disorders (Drug Abuse)
10/2023 - 07/2013
6Pain (Aches)
01/2022 - 01/2015
5Opioid-Related Disorders (Opiate Addiction)
10/2023 - 01/2019
5Neoplasms (Cancer)
09/2022 - 01/2019
5Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
01/2014 - 12/2006
4Obesity
12/2008 - 12/2006
3Acquired Immunodeficiency Syndrome (AIDS)
03/2011 - 06/2010
3Alcoholism (Alcohol Abuse)
12/2008 - 01/2007
3Substance Withdrawal Syndrome (Withdrawal Symptoms)
12/2008 - 06/2002
2Pruritus (Itching)
01/2022 - 12/2021
2Inflammation (Inflammations)
01/2022 - 12/2019
2Neuroinflammatory Diseases
01/2022 - 12/2019
2Schizophrenia (Dementia Praecox)
01/2022 - 01/2021
2Tobacco Use Disorder (Nicotine Dependence)
12/2010 - 09/2010
1Respiratory Insufficiency (Respiratory Failure)
05/2024
1Neuralgia (Stump Neuralgia)
10/2023
1Renal Cell Carcinoma (Grawitz Tumor)
09/2022
1Colonic Neoplasms (Colon Cancer)
01/2022
1Parkinson Disease (Parkinson's Disease)
01/2022
1Hypoxia (Hypoxemia)
01/2021
1Brain Hypoxia (Cerebral Hypoxia)
12/2020
1Neoplasm Metastasis (Metastasis)
07/2020
1Prostatic Neoplasms (Prostate Cancer)
03/2020
1B-Cell Lymphoma (Lymphoma, B Cell)
03/2020
1Hearing Loss (Hearing Impairment)
01/2020
1Gram-Negative Bacterial Infections
01/2020
1Deafness (Deaf Mutism)
01/2020
1Hyperthermia
03/2019
1Disease Progression
03/2019
1Lung Neoplasms (Lung Cancer)
01/2019
1Choriocarcinoma
07/2018

Drug/Important Bio-Agent (IBA)

12Cocaine (Cocaine HCl)IBA
01/2020 - 06/2005
8Serotonin (5 Hydroxytryptamine)IBA
01/2015 - 06/2002
7Dopamine (Intropin)FDA LinkGeneric
03/2023 - 06/2002
6Bupropion (Wellbutrin)FDA LinkGeneric
01/2014 - 11/2009
5Opioid Analgesics (Opioids)IBA
05/2024 - 11/2018
5Methamphetamine (Desoxyn)FDA LinkGeneric
03/2023 - 12/2008
4Norepinephrine (Noradrenaline)FDA LinkGeneric
03/2023 - 03/2011
4mu Opioid Receptors (mu Opioid Receptor)IBA
11/2022 - 12/2020
4NicotineFDA Link
01/2014 - 06/2010
3G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
10/2023 - 01/2021
3Oxycodone (Oxycontin)FDA LinkGeneric
12/2021 - 11/2018
3Analgesics (Analgesic Drugs)IBA
01/2021 - 01/2015
3phendimetrazine (Bontril)FDA LinkGeneric
01/2020 - 04/2016
3Neurotransmitter Agents (Neurotransmitter)IBA
03/2019 - 06/2002
2Fentanyl (Sublimaze)FDA LinkGeneric
05/2024 - 11/2022
2TriazolesIBA
10/2023 - 12/2021
2Methadone (Dolophine)FDA LinkGeneric
11/2022 - 12/2020
2AlkaloidsIBA
01/2022 - 03/2020
2Synthetic CathinoneIBA
01/2022 - 10/2012
2oxymatrineIBA
11/2021 - 01/2019
2GTP-Binding Proteins (G-Protein)IBA
01/2021 - 12/2020
2((3- methoxythiophen- 2- yl)methyl)((2- (9- (pyridin- 2- yl)- 6- oxaspiro(4.5)decan- 9- yl)ethyl))amineIBA
01/2021 - 12/2020
2Appetite Depressants (Anorectics)IBA
12/2016 - 04/2016
2Phenmetrazine (Preludin)FDA Link
07/2015 - 08/2013
2Amphetamine (Amfetamine)FDA LinkGeneric
06/2014 - 11/2009
2N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA
01/2014 - 11/2009
2Antidepressive Agents (Antidepressants)IBA
01/2014 - 06/2010
2Dextroamphetamine (Dexedrine)FDA LinkGeneric
08/2013 - 06/2013
2hydroxybupropionIBA
09/2010 - 06/2010
1CatecholaminesIBA
03/2023
1tanshinoneIBA
09/2022
1CateninsIBA
09/2022
1Trace Amine-Associated ReceptorsIBA
01/2022
1Proteins (Proteins, Gene)FDA Link
01/2022
1Thymidine Monophosphate (TMP)IBA
01/2022
1CytokinesIBA
01/2022
1Superoxide DismutaseIBA
01/2022
1kappa Opioid Receptors (kappa Opioid Receptor)IBA
01/2022
1Trace amine-associated receptor 1IBA
01/2021
1Buprenorphine (Subutex)FDA LinkGeneric
12/2020
1CXC ChemokinesIBA
07/2020
1MatrinesIBA
07/2020
1Matrix Metalloproteinases (MMPs)IBA
07/2020
1indoloquinazolineIBA
03/2020
1evodiamineIBA
03/2020
1SurvivinIBA
03/2020
1NF-kappa B (NF-kB)IBA
03/2020
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
03/2020
1Cyclin D1IBA
03/2020
1Mitogen-Activated Protein KinasesIBA
03/2020
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2020
1Metalloproteases (Metalloproteinases)IBA
03/2020
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
03/2020
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
03/2020
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
03/2020
1berbamine (penduline)IBA
01/2020
1AminoglycosidesIBA
01/2020
1Anti-Bacterial Agents (Antibiotics)IBA
01/2020
1Ethanol (Ethyl Alcohol)IBA
12/2019
1Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2019
1Hallucinogens (Psychedelics)IBA
12/2019
1Paclitaxel (Taxol)FDA LinkGeneric
01/2019
1Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA
07/2018

Therapy/Procedure

7Therapeutics
12/2021 - 12/2006
5Self Administration (Administration, Self)
05/2024 - 06/2005
4Drug Therapy (Chemotherapy)
12/2016 - 11/2009
1Secondary Prevention
12/2020
1Castration
03/2020