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Bruce Beutler Selected Research

Immunotherapy

12/2023Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity.
11/2018Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice.

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Bruce Beutler Research Topics

Disease

29Infections
01/2024 - 10/2001
14Virus Diseases (Viral Diseases)
01/2024 - 01/2003
9Neoplasms (Cancer)
06/2024 - 07/2015
9Colitis
01/2023 - 03/2009
8Inflammation (Inflammations)
01/2023 - 06/2007
6Obesity
11/2022 - 12/2006
5Lymphopenia (Lymphocytopenia)
12/2023 - 05/2007
5Autoimmune Diseases (Autoimmune Disease)
11/2021 - 05/2007
4Melanoma (Melanoma, Malignant)
01/2019 - 05/2006
3Hypersensitivity (Allergy)
01/2024 - 01/2008
3Splenomegaly
12/2023 - 02/2013
3Insulin Resistance
01/2020 - 10/2016
3Vesicular Stomatitis
07/2007 - 06/2005
3Sepsis (Septicemia)
06/2003 - 10/2001
2Non-alcoholic Fatty Liver Disease
01/2022 - 01/2019
2Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2022 - 11/2021
2Body Weight (Weight, Body)
01/2022 - 01/2010
2Hyperglycemia
01/2020 - 01/2018
2Lipodystrophy
01/2020 - 10/2016
2Hypopigmentation (Hypomelanosis)
01/2020 - 08/2012
2Lymphadenopathy
12/2018 - 02/2013
2Alopecia (Baldness)
01/2017 - 12/2005
2Waldenstrom Macroglobulinemia (Macroglobulinemia)
01/2016 - 03/2014
2Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
01/2016 - 03/2014
2Cardiomyopathies (Cardiomyopathy)
01/2016 - 12/2011
2Nephritis
11/2009 - 04/2009
2Iron Deficiencies
11/2009 - 05/2008
2Glomerulonephritis
11/2009 - 04/2009
2Atherosclerosis
10/2009 - 12/2002
2Cataract (Cataracts)
05/2006 - 07/2005
2Legionnaires' Disease (Legionnaire's Disease)
02/2005 - 11/2003
1Carcinogenesis
02/2024
1Microcephaly
11/2023
1Neurodevelopmental Disorders
11/2023
1Epilepsy (Aura)
11/2023
1Congenital Abnormalities (Deformity)
01/2021
1Alzheimer Disease (Alzheimer's Disease)
01/2020
1Hidradenitis Suppurativa
01/2020
1Hyperinsulinism (Hyperinsulinemia)
01/2020
1Retinal Diseases
01/2020
1Hypergammaglobulinemia (Hyperimmunoglobulinemia)
01/2020

Drug/Important Bio-Agent (IBA)

18Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA
01/2022 - 09/2004
17Toll-Like Receptors (Toll-Like Receptor)IBA
12/2018 - 10/2001
13Proteins (Proteins, Gene)FDA Link
12/2023 - 09/2004
8CytokinesIBA
01/2024 - 05/2007
8LigandsIBA
01/2024 - 11/2003
8LipidsIBA
12/2023 - 08/2005
7Dextrans (Dextran)FDA Link
01/2023 - 03/2009
6Insulin (Novolin)FDA Link
02/2024 - 01/2010
6sodium sulfate (sodium bisulfate)FDA LinkGeneric
01/2023 - 03/2009
6Antiviral Agents (Antivirals)IBA
10/2015 - 06/2007
5LipopolysaccharidesIBA
01/2024 - 01/2006
5Interferon Type IIBA
01/2024 - 01/2003
5AntigensIBA
11/2018 - 03/2005
4Glucose (Dextrose)FDA LinkGeneric
02/2024 - 01/2018
4DNA (Deoxyribonucleic Acid)IBA
01/2022 - 12/2007
3Messenger RNA (mRNA)IBA
10/2019 - 11/2009
3IronIBA
12/2011 - 05/2008
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2010 - 02/2003
3Toll-Like Receptor 4IBA
02/2005 - 12/2002
2VaccinesIBA
01/2024 - 06/2006
2Retinaldehyde (Retinal)IBA
01/2020 - 07/2005
2Nonsense Codon (Nonsense Mutation)IBA
01/2019 - 09/2008
2diprovocimIBA
01/2019 - 11/2018
2CholesterolIBA
01/2018 - 01/2017
2Mechanistic Target of Rapamycin Complex 1IBA
01/2018 - 05/2014
2Immunoglobulin M (IgM)IBA
12/2014 - 03/2014
2Adenosine Triphosphate (ATP)IBA
07/2011 - 12/2007
2KATP ChannelsIBA
07/2011 - 12/2007
2Interleukin-12 (IL 12)IBA
07/2011 - 08/2010
2site 1 membrane-bound transcription factor peptidaseIBA
03/2011 - 03/2009
2Antigen-Antibody Complex (Immune Complex)IBA
03/2010 - 04/2009
2HepcidinsIBA
11/2009 - 05/2008
2Glycoproteins (Glycoprotein)IBA
10/2009 - 06/2007
2DiglyceridesIBA
10/2009 - 09/2006
2GlycolipidsIBA
09/2006 - 03/2005
2EndotoxinsIBA
03/2006 - 05/2003
2Toll-Like Receptor 2IBA
08/2005 - 06/2005
1midnolinIBA
06/2024
1Scavenger Receptors (Scavenger Receptor)IBA
03/2024
1interferon-alpha 8IBA
03/2024
1Insulin-Like PeptidesIBA
02/2024
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
02/2024
1Interleukin-10 (Interleukin 10)IBA
01/2024
1Interleukin-6 (Interleukin 6)IBA
01/2024
1Immune Checkpoint InhibitorsIBA
12/2023
1Membrane Proteins (Integral Membrane Proteins)IBA
11/2023
1Mixed Function Oxygenases (Monooxygenases)IBA
01/2023
1Transcription Factors (Transcription Factor)IBA
11/2022
1GTP Phosphohydrolases (GTPases)IBA
01/2022
1Dual-Specificity PhosphatasesIBA
11/2021
1Antigen Receptors (Antigen Receptor)IBA
01/2021
1Sulfoglycosphingolipids (Sulfatides)IBA
01/2021
1CarcinogensIBA
01/2020
1Immunoglobulin G (IgG)IBA
01/2020
1Immunoglobulin E (IgE)IBA
01/2020
1Immunoglobulin A (IgA)IBA
01/2020
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2020

Therapy/Procedure

3Therapeutics
01/2024 - 12/2011
2Immunotherapy
12/2023 - 11/2018