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Brian Bernick Selected Research

Estradiol (Delestrogen)

11/2022Review of menopausal hormone therapy with estradiol and progesterone versus other estrogens and progestins.
11/2020Estradiol softgel inserts for the treatment of VVA symptoms: an expert opinion.
1/2020Endometrial safety and bleeding profile of a 17β-estradiol/progesterone oral softgel capsule (TX-001HR).
12/2018Estradiol vaginal inserts (4 µg and 10 µg) for treating moderate to severe vulvar and vaginal atrophy: a review of phase 3 safety, efficacy and pharmacokinetic data.
1/2018A 17β-Estradiol-Progesterone Oral Capsule for Vasomotor Symptoms in Postmenopausal Women: A Randomized Controlled Trial.
5/2017A vaginal estradiol softgel capsule, TX-004HR, has negligible to very low systemic absorption of estradiol: Efficacy and pharmacokinetic data review.
1/2017The REJOICE trial: a phase 3 randomized, controlled trial evaluating the safety and efficacy of a novel vaginal estradiol soft-gel capsule for symptomatic vulvar and vaginal atrophy.
1/2017Consistency of Effect with a Low-Dose, Estradiol Vaginal Capsule (TX-004HR): Evaluating Improvement in Vaginal Physiology and Moderate-to-Severe Dyspareunia in Subgroups of Postmenopausal Women.
1/2017TX-004HR vaginal estradiol has negligible to very low systemic absorption of estradiol.

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Brian Bernick Research Topics

Disease

12Atrophy
11/2020 - 12/2016
8Dyspareunia
11/2020 - 12/2016
5Endometrial Hyperplasia
11/2022 - 01/2018
2Breast Neoplasms (Breast Cancer)
11/2022 - 01/2019
2Neoplasms (Cancer)
11/2022 - 01/2019
2Hyperplasia
01/2019 - 01/2019
1Cognitive Dysfunction
11/2022
1Bone Fractures (Bone Fracture)
11/2022
1Venous Thromboembolism
11/2022
1Amenorrhea
01/2020
1Metrorrhagia (Spotting)
01/2020
1Hemorrhage
01/2020
1Endometrial Neoplasms (Endometrial Cancer)
01/2019
1Sleepiness
12/2018
1Pruritus (Itching)
05/2017

Drug/Important Bio-Agent (IBA)

9Estradiol (Delestrogen)FDA LinkGeneric
11/2022 - 01/2017
8Capsules (Microcapsules)IBA
01/2020 - 01/2017
8TX-004HRIBA
09/2017 - 12/2016
4Estrogens (Estrogen)FDA Link
11/2022 - 01/2017
4ProgesteroneFDA LinkGeneric
11/2022 - 01/2018
3TX-001HRIBA
01/2020 - 12/2018
2Progestins (Progestagens)IBA
11/2022 - 01/2019
2Conjugated (USP) Estrogens (Premarin)FDA Link
11/2022 - 01/2019
1mahuang-tangIBA
11/2022
1Hormones (Hormone)IBA
11/2022
1Progesterone CongenersIBA
11/2022

Therapy/Procedure

3Therapeutics
11/2022 - 01/2017