Alvin J Beitz Selected Research

N- (2- (3,4- Dichlorphenyl)ethyl)- N,N',N'- trimethyl- 1,2- ethandiamin

12/2016	Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice.
3/2016	Peripheral neurosteroids enhance P2X receptor-induced mechanical allodynia via a sigma-1 receptor-mediated mechanism.
10/2015	Spinal sigma-1 receptor activation increases the production of D-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain.
8/2013	Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats.
6/2009	Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors.
11/2008	Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain.
6/2006	Intrathecal treatment with sigma1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice.

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Alvin J Beitz Research Topics

Disease

44	Hyperalgesia 01/2023 - 01/2003
40	Pain (Aches) 01/2023 - 02/2001
21	Neuralgia (Stump Neuralgia) 01/2023 - 08/2004
16	Inflammation (Inflammations) 01/2018 - 01/2003
7	Neoplasms (Cancer) 05/2016 - 01/2003
5	Peripheral Nervous System Diseases (PNS Diseases) 01/2023 - 08/2004
5	Hypersensitivity (Allergy) 02/2018 - 08/2011
5	Arthritis (Polyarthritis) 12/2004 - 02/2001
4	Chronic Pain 01/2023 - 08/2004
4	Thrombosis (Thrombus) 01/2014 - 10/2008
4	Ischemia 01/2012 - 10/2008
4	Edema (Dropsy) 03/2008 - 02/2001
3	Peripheral Nerve Injuries 08/2019 - 01/2017
3	Fibrosarcoma 09/2007 - 01/2003
2	Hypotension (Low Blood Pressure) 05/2016 - 03/2009
2	Cancer Pain 11/2014 - 01/2013
2	Bone Neoplasms (Bone Cancer) 11/2014 - 01/2003
2	Hypoxia (Hypoxemia) 01/2014 - 10/2008
2	Spinal Cord Injuries (Spinal Cord Injury) 01/2013 - 07/2010
2	Acidosis 03/2011 - 08/2010
2	Sarcoma (Soft Tissue Sarcoma) 02/2009 - 01/2003
2	Multiple Sclerosis 06/2008 - 01/2008
2	Rheumatoid Arthritis 05/2002 - 02/2001
1	Nervous System Trauma 01/2023
1	Migraine Disorders (Migraine) 02/2018

Drug/Important Bio-Agent (IBA)

13	Bee Venoms (Bee Venom)IBA 03/2016 - 02/2001
10	Analgesics (Analgesic Drugs)IBA 01/2023 - 02/2001
10	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 12/2021 - 06/2006
10	Sigma-1 ReceptorIBA 12/2021 - 12/2008
8	N-Methylaspartate (NMDA)IBA 12/2021 - 02/2010
8	CarrageenanIBA 01/2018 - 01/2003
7	Formaldehyde (Formol)FDA Link 01/2018 - 03/2003
7	N- (2- (3,4- Dichlorphenyl)ethyl)- N,N',N'- trimethyl- 1,2- ethandiaminIBA 12/2016 - 06/2006
6	EnzymesIBA 01/2023 - 01/2019
6	Capsaicin (Zostrix)FDA Link 02/2018 - 09/2007
5	CytochromesIBA 01/2023 - 01/2019
5	2- (4- morpholino)ethyl- 1- phenylcyclohexane- 1- carboxylateIBA 12/2021 - 11/2008
5	Adrenergic Receptors (Adrenergic Receptor)IBA 05/2016 - 11/2011
5	Clonidine (ST 155)FDA LinkGeneric 05/2016 - 07/2008
4	Ketoconazole (Nizoral)FDA LinkGeneric 01/2023 - 01/2019
4	NeurosteroidsIBA 10/2019 - 06/2009
4	p38 Mitogen-Activated Protein KinasesIBA 10/2019 - 09/2013
4	Proteins (Proteins, Gene)FDA Link 08/2019 - 05/2005
4	Serine (L-Serine)FDA Link 01/2019 - 10/2015
4	Morphine (MS Contin)FDA LinkGeneric 11/2014 - 01/2003
4	Opioid Analgesics (Opioids)IBA 11/2014 - 02/2004
4	CatecholaminesIBA 10/2007 - 09/2005
3	SB 203580IBA 10/2019 - 04/2014
3	Messenger RNA (mRNA)IBA 08/2019 - 09/2007
3	Dehydroepiandrosterone (DHEA)IBA 08/2019 - 06/2009
3	LigandsIBA 01/2019 - 09/2007
3	Purinergic P2Y1 ReceptorsIBA 01/2017 - 01/2014
3	Adenosine Triphosphate (ATP)IBA 01/2014 - 08/2010
3	ZymosanIBA 05/2007 - 07/2005
3	Freund's AdjuvantIBA 12/2002 - 02/2001
2	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 12/2021 - 01/2017
2	Protein Isoforms (Isoforms)IBA 11/2019 - 06/2010
2	fluorocitrateIBA 01/2019 - 12/2016
2	serine racemaseIBA 01/2019 - 01/2017
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2019 - 01/2017
2	Mitogen-Activated Protein KinasesIBA 01/2017 - 04/2014
2	Connexin 43 (Connexin43)IBA 01/2017 - 12/2016
2	2- iodo- N(6)- methyl- (N)- methanocarba- 2'- deoxyadenosine- 3',5'- bisphosphateIBA 01/2017 - 04/2014
2	Peptides (Polypeptides)IBA 12/2016 - 09/2007
2	CarbenoxoloneIBA 12/2016 - 07/2010
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 05/2016 - 03/2016
2	Opiate AlkaloidsIBA 11/2014 - 01/2008
2	Therapeutic UsesIBA 01/2013 - 02/2001
2	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 02/2012 - 09/2008
2	BicucullineIBA 11/2010 - 06/2009
2	GABA-A Receptor AntagonistsIBA 11/2010 - 06/2009
2	Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)IBA 02/2010 - 08/2008
2	Gabapentin (Neurontin)FDA LinkGeneric 08/2008 - 09/2007
2	Neostigmine (Neostigmine Bromide)IBA 07/2008 - 09/2005
2	Opioid Receptors (Opioid Receptor)IBA 01/2008 - 08/2004
1	Glial Fibrillary Acidic ProteinIBA 01/2023
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2023
1	Mifepristone (RU 486)FDA Link 01/2023
1	Progesterone FDA LinkGeneric 01/2023
1	Finasteride (Propecia)FDA LinkGeneric 01/2023
1	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 11/2019
1	2- ((1H- benzo(d)(1,2,3)triazol- 5- ylamino)methyl)- 4,6- dichlorophenolIBA 11/2019
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 08/2019
1	trilostane FDA Link 01/2019
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2019
1	Aminoglutethimide (Cytadren)FDA Link 01/2019
1	Oxidoreductases (Dehydrogenase)IBA 01/2019
1	Nitroglycerin (Dynamite)FDA LinkGeneric 02/2018
1	resiniferatoxinIBA 02/2018
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2018

Therapy/Procedure

10	Acupuncture Points (Acupuncture Point) 03/2016 - 02/2001
5	Therapeutics 01/2023 - 02/2001
5	Spinal Injections 12/2016 - 11/2008
5	Electroacupuncture 01/2013 - 01/2006
3	Drug Therapy (Chemotherapy) 05/2016 - 01/2003
2	Injections 01/2014 - 02/2001
2	Acupuncture Therapy 01/2013 - 01/2006
2	Complementary Therapies (Alternative Medicine) 01/2013 - 02/2001
2	Subcutaneous Injections 03/2009 - 02/2005
2	East Asian Traditional Medicine (Oriental Medicine) 08/2004 - 02/2001