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Richard Bayliss Selected Research

Therapeutics

1/2021Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma.
11/2020Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma.
1/2020Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
3/2017Structure-guided design of purine-based probes for selective Nek2 inhibition.
11/2016Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.
1/2016Targeting cancer stem-like cells using dietary-derived agents - Where are we now?

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Richard Bayliss Research Topics

Disease

24Neoplasms (Cancer)
11/2023 - 02/2009
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2023 - 04/2014
5Neuroblastoma
06/2023 - 11/2016
2Lung Neoplasms (Lung Cancer)
01/2022 - 09/2017
2Aneuploidy (Aneuploid)
07/2015 - 11/2009
1Ataxia Telangiectasia (Louis Bar Syndrome)
01/2021
1Adenocarcinoma of Lung
09/2017
1Genomic Instability
04/2016
1Autoimmune Diseases (Autoimmune Disease)
01/2016
1Reperfusion Injury
01/2016
1Inflammation (Inflammations)
01/2016
1Lymphoma (Lymphomas)
10/2015
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2012
1Cystic Kidney Diseases (Cystic Kidney Disease)
03/2012
1Body Weight (Weight, Body)
07/2010
1Carcinoma (Carcinomatosis)
07/2010

Drug/Important Bio-Agent (IBA)

13Proteins (Proteins, Gene)FDA Link
01/2022 - 11/2009
7Phosphotransferases (Kinase)IBA
01/2021 - 02/2009
6Protein Kinases (Protein Kinase)IBA
06/2020 - 11/2009
5Anaplastic Lymphoma KinaseIBA
06/2023 - 04/2014
3Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
06/2023 - 03/2016
3Aurora KinasesIBA
11/2017 - 03/2010
2Transcription Factors (Transcription Factor)IBA
01/2021 - 11/2020
2Oncogene Proteins (Oncogene Protein)IBA
01/2021 - 04/2014
1Immune Checkpoint InhibitorsIBA
11/2023
1VaccinesIBA
11/2023
1PoisonsIBA
01/2022
1Paclitaxel (Taxol)FDA LinkGeneric
01/2022
1Adrenergic Agents (Adrenergic Drugs)IBA
11/2020
1Temozolomide (Temodar)FDA LinkGeneric
11/2020
1CYC065IBA
11/2020
1EnzymesIBA
06/2020
1HoloenzymesIBA
11/2017
1KinesinsIBA
11/2017
1UbiquitinIBA
11/2016
1MLN 8237IBA
11/2016
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
11/2016
1Proteasome Endopeptidase Complex (Proteasome)IBA
11/2016
1N-Myc Proto-Oncogene ProteinIBA
11/2016
1SecurinIBA
04/2016
1SeparaseIBA
04/2016
1Interleukin-16 (Interleukin 16)IBA
01/2016
1Gingipain Cysteine EndopeptidasesIBA
10/2015
1CaspasesIBA
10/2015
1Alanine (L-Alanine)FDA Link
07/2015
1ClathrinIBA
08/2013
1benzocycloheptapyridineIBA
10/2012
1Biomarkers (Surrogate Marker)IBA
10/2012
1Aurora Kinase AIBA
11/2009

Therapy/Procedure

6Therapeutics
01/2021 - 01/2016
2Oral Administration
10/2012 - 07/2010
1Molecular Targeted Therapy
09/2017
1Drug Therapy (Chemotherapy)
01/2016