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Dominique Bédard Selected Research

1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)

10/2023The mGluR2/3 orthosteric agonist LY-404,039 reduces dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.
10/2023Effect of the mGlu4 positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset.
7/2023The 5-HT2A/2C inverse agonist nelotanserin alleviates L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset.
8/2022Effect of glycine transporter 1 inhibition with bitopertin on parkinsonism and L-DOPA induced dyskinesia in the 6-OHDA-lesioned rat.
1/2021Selective blockade of the 5-HT3 receptor acutely alleviates dyskinesia and psychosis in the parkinsonian marmoset.
1/2021Effect of the mGlu2 positive allosteric modulator CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.
1/2021Combined 5-HT2A and mGlu2 modulation for the treatment of dyskinesia and psychosis in Parkinson's disease.
11/2020Monoamine oxidase A inhibition as monotherapy reverses parkinsonism in the MPTP-lesioned marmoset.
11/2020Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset.
4/2020Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset.
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Dominique Bédard Research Topics

Disease

23Dyskinesias (Dyskinesia)
04/2024 - 01/2018
20Parkinson Disease (Parkinson's Disease)
04/2024 - 01/2018
14Psychotic Disorders (Schizoaffective Disorder)
10/2023 - 01/2018
12Parkinsonian Disorders (Parkinsonism)
10/2023 - 12/2018
3Schizophrenia (Dementia Praecox)
10/2023 - 09/2018
2Epilepsy (Aura)
07/2020 - 10/2019
2Neoplasms (Cancer)
11/2009 - 06/2009
1Drug-Induced Dyskinesia (Dyskinesia, Drug Induced)
07/2023
1Dementia (Dementias)
07/2023
1Mental Disorders (Mental Disorder)
09/2018
1Sarcoma (Soft Tissue Sarcoma)
11/2009
1Glioblastoma (Glioblastoma Multiforme)
11/2009
1Neuroblastoma
11/2009
1Lymphoma (Lymphomas)
06/2009
1Multiple Myeloma
06/2009
1Carcinoma (Carcinomatosis)
06/2009
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
06/2009

Drug/Important Bio-Agent (IBA)

24Levodopa (L Dopa)FDA LinkGeneric
04/2024 - 01/2018
161- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
10/2023 - 01/2018
11Serotonin (5 Hydroxytryptamine)IBA
07/2023 - 01/2018
9Oxidopamine (6 Hydroxydopamine)IBA
04/2024 - 01/2019
6Glutamic Acid (Glutamate)FDA Link
04/2024 - 09/2018
6Ondansetron (Zofran)FDA LinkGeneric
04/2022 - 10/2019
3salicylhydroxamic acid (SHAM)IBA
04/2024 - 04/2022
3metabotropic glutamate receptor 2IBA
10/2023 - 09/2018
3Dopamine (Intropin)FDA LinkGeneric
10/2023 - 03/2020
3Granisetron (Kytril)FDA LinkGeneric
04/2022 - 01/2021
35-HT2A Serotonin Receptor (5 HT2A Receptor)IBA
02/2019 - 01/2018
2ProdrugsIBA
10/2023 - 11/2009
2(4- (3- fluoro- 5- trifluoromethylpyridin- 2- yl)piperazin- 1- yl)(5- methanesulfonyl- 2- (2,2,2- trifluoro- 1- methylethoxy)phenyl)methanoneIBA
01/2023 - 08/2022
2Glycine Plasma Membrane Transport ProteinsIBA
01/2023 - 08/2022
25-HT3 Serotonin Receptors (5 HT3 Receptor)IBA
01/2021 - 03/2020
2Monoamine Oxidase (MAO)IBA
11/2020 - 11/2020
2Moclobemide (Arima)IBA
11/2020 - 11/2020
2N- (6- chlorophenoxyhexyl)- N''- cyano- N''- 4- pyridylguanidine (CHS 828)IBA
11/2009 - 06/2009
2NAD (NADH)IBA
11/2009 - 06/2009
21- (2- (2- (2- (2- methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)- 4- (N'- cyano- N''- (6- (4- chlorophenoxy)hexyl)- N- guanidino)pyridiniumIBA
11/2009 - 06/2009
1LY 2140023IBA
10/2023
1nelotanserinIBA
07/2023
1(R)- (N- (3- (4'- fluorophenyl)- 3- (4'- phenylphenoxy)propyl))sarcosineIBA
08/2022
1alpha-SynucleinIBA
01/2022
1Serotonin 5-HT3 Receptor AntagonistsIBA
01/2021
1Therapeutic UsesIBA
01/2021
1EnzymesIBA
11/2020
1nefazodone (Serzone)FDA LinkGeneric
12/2018
1Serotonin 5-HT2 Receptor AntagonistsIBA
01/2018
1Messenger RNA (mRNA)IBA
11/2009
1nicotinate phosphoribosyltransferaseIBA
11/2009
1Proteins (Proteins, Gene)FDA Link
11/2009

Therapy/Procedure

5Therapeutics
01/2021 - 11/2009
1Intravenous Injections
06/2009
1Intravenous Infusions
06/2009