Ottavio Arancio Selected Research

Therapeutics

1/2023	Optimizing metabolic stability of phosphodiesterase 5 inhibitors: Discovery of a potent N-(pyridin-3-ylmethyl)quinoline derivative targeting synaptic plasticity.
1/2020	Stem Cell Therapy for Alzheimer's Disease.
1/2020	Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer's disease.
1/2019	Efficient Expression of HIV in Immunocompetent Mouse Brain Reveals a Novel Nonneurotoxic Viral Function in Hippocampal Synaptodendritic Injury and Memory Impairment.
1/2019	Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory.
1/2018	A role for tau in learning, memory and synaptic plasticity.
1/2018	EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment.
1/2016	Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease.
2/2015	Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies.
1/2015	Synaptic therapy in Alzheimer's disease: a CREB-centric approach.

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Ottavio Arancio Research Topics

Disease

88	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 08/2002
17	Memory Disorders (Memory Loss) 08/2020 - 12/2004
16	Cognitive Dysfunction 01/2023 - 06/2004
12	Dementia (Dementias) 07/2023 - 06/2007
8	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 06/2007
5	Tauopathies 08/2020 - 11/2010
5	Amyloid Plaque 07/2015 - 05/2008
4	Schizophrenia (Dementia Praecox) 01/2014 - 08/2006
3	Erectile Dysfunction 07/2023 - 04/2008
3	Disease Progression 04/2015 - 06/2004
3	familial Danish Dementia 03/2012 - 11/2010
2	Autistic Disorder (Autism) 01/2022 - 01/2006
2	Ischemia 01/2022 - 06/2014
2	Infections 01/2022 - 01/2018
2	Inflammation (Inflammations) 01/2022 - 01/2013
2	Neuroinflammatory Diseases 08/2020 - 10/2018
2	Pulmonary Hypertension 01/2020 - 04/2008
2	Acquired Immunodeficiency Syndrome (AIDS) 01/2019 - 01/2018
2	Parkinson Disease (Parkinson's Disease) 01/2019 - 01/2017
2	AIDS-Related Complex (ARC) 01/2019 - 12/2007
2	Vomiting 12/2017 - 11/2016
2	Mitochondrial Diseases (Mitochondrial Disease) 09/2015 - 04/2004
2	Fatigue 01/2014 - 04/2005
2	Down Syndrome (Down's Syndrome) 02/2013 - 07/2008
1	Pulmonary Arterial Hypertension 07/2023
1	Heart Failure 01/2023
1	Wounds and Injuries (Trauma) 01/2022
1	Tuberous Sclerosis (Bourneville's Disease) 01/2022
1	Epilepsy (Aura) 01/2022
1	Gaucher Disease (Gaucher's Disease) 01/2019
1	HIV Infections (HIV Infection) 01/2019

Drug/Important Bio-Agent (IBA)

39	Amyloid (Amyloid Fibrils)IBA 01/2024 - 01/2003
31	Amyloid beta-PeptidesIBA 12/2023 - 04/2004
24	Peptides (Polypeptides)IBA 01/2023 - 04/2004
23	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2003
6	tau Proteins (tau Protein)IBA 11/2022 - 07/2015
6	CalpainIBA 01/2016 - 08/2002
4	Sildenafil Citrate (Viagra)FDA Link 07/2023 - 04/2008
4	Phosphodiesterase 5 InhibitorsIBA 07/2023 - 02/2013
4	Protein Isoforms (Isoforms)IBA 08/2020 - 04/2015
4	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2018 - 05/2011
4	Presenilin-1IBA 01/2018 - 04/2005
4	CalciumIBA 11/2017 - 09/2004
4	calpain inhibitorsIBA 01/2016 - 08/2002
3	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2023 - 08/2012
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2022 - 01/2006
3	ElementsIBA 08/2020 - 01/2019
3	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2020 - 06/2009
3	EnzymesIBA 01/2019 - 04/2005
3	Flavin-Adenine Dinucleotide (FAD)IBA 01/2017 - 01/2013
3	Brain-Derived Neurotrophic Factor (BDNF)IBA 03/2014 - 08/2006
2	Serotonin (5 Hydroxytryptamine)IBA 01/2024 - 01/2012
2	Tadalafil (Cialis)FDA Link 07/2023 - 01/2020
2	Vardenafil Dihydrochloride (Levitra)FDA Link 07/2023 - 01/2020
2	Serine (L-Serine)FDA Link 01/2021 - 08/2012
2	Threonine (L-Threonine)FDA Link 01/2021 - 01/2013
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 08/2008
2	Carrier Proteins (Binding Protein)IBA 01/2020 - 01/2014
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2020 - 01/2019
2	Phosphotransferases (Kinase)IBA 01/2019 - 04/2015
2	Beclin-1IBA 01/2019 - 10/2014
2	Histones (Histone)IBA 01/2019 - 01/2009
2	Receptor for Advanced Glycation End ProductsIBA 01/2018 - 12/2007
2	quinolineIBA 11/2017 - 02/2013
2	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA 08/2013 - 01/2008
2	synaptojaninIBA 10/2012 - 07/2008
2	GlutaminaseIBA 05/2012 - 09/2009
2	Glutamic Acid (Glutamate)FDA Link 05/2012 - 04/2004
1	Amyloidogenic ProteinsIBA 01/2024
1	5-HT2B Serotonin ReceptorIBA 01/2024
1	Vasodilator Agents (Vasodilators)IBA 07/2023
1	Single-Chain AntibodiesIBA 01/2023
1	Antimicrobial PeptidesIBA 01/2022
1	Tryptophan (L-Tryptophan)FDA Link 01/2022
1	trans-sodium crocetinate (crocetin)IBA 01/2022
1	Cholinergic Agents (Cholinergics)IBA 11/2021
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 11/2021
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2021
1	p38 Mitogen-Activated Protein KinasesIBA 08/2020
1	Adenine FDA LinkGeneric 01/2020
1	Sirolimus (Rapamycin)FDA Link 01/2019
1	mesoxalonitrileIBA 01/2019
1	mitotracker green FMIBA 01/2019
1	PTEN-induced putative kinaseIBA 01/2019
1	Red Fluorescent ProteinIBA 01/2019
1	Carbonyl Cyanide m-Chlorophenyl Hydrazone (CCCP)IBA 01/2019
1	Glucosylceramidase (Glucocerebrosidase)IBA 01/2019
1	Lysine (L-Lysine)FDA Link 01/2019
1	Viral ProteinsIBA 01/2019
1	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 01/2019
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019
1	PorinsIBA 01/2019
1	Matrix Metalloproteinases (MMPs)IBA 01/2019
1	Dynamin IIBA 01/2019
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2019
1	Cytochromes c (Cytochrome c)IBA 01/2019

Therapy/Procedure

15	Therapeutics 01/2023 - 07/2003
2	Intraperitoneal Injections 03/2014 - 10/2008
1	Immunotherapy 01/2023
1	Precision Medicine 12/2021