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Leonard J Appleman Selected Research

Neoplasms (Cancer)

11/2023Phase I LITESPARK-001 study of belzutifan for advanced solid tumors: Extended 41-month follow-up in the clear cell renal cell carcinoma cohort.
10/2023Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study.
4/2023A phase 1 study of veliparib (ABT-888) plus weekly carboplatin and paclitaxel in advanced solid malignancies, with an expansion cohort in triple negative breast cancer (TNBC) (ETCTN 8620).
10/2022Efficacy and Safety of Telaglenastat Plus Cabozantinib vs Placebo Plus Cabozantinib in Patients With Advanced Renal Cell Carcinoma: The CANTATA Randomized Clinical Trial.
1/2022HLA-A*03 and response to immune checkpoint blockade in patients with cancer.
10/2021Phase 1 study of safety, pharmacokinetics, and pharmacodynamics of tivantinib in combination with bevacizumab in adult patients with advanced solid tumors.
1/2021Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis.
10/2020A randomized phase 2 trial of pembrolizumab versus pembrolizumab and acalabrutinib in patients with platinum-resistant metastatic urothelial cancer.
1/2020PSMA ADC monotherapy in patients with progressive metastatic castration-resistant prostate cancer following abiraterone and/or enzalutamide: Efficacy and safety in open-label single-arm phase 2 study.
1/2020CD8+ T Cells Impact Rising PSA in Biochemically Relapsed Cancer Patients Using Immunotherapy Targeting Tumor-Associated Antigens.
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Leonard J Appleman Research Topics

Disease

26Neoplasms (Cancer)
11/2023 - 11/2005
22Renal Cell Carcinoma (Grawitz Tumor)
03/2024 - 12/2009
11Prostatic Neoplasms (Prostate Cancer)
11/2023 - 12/2010
4Fatigue
10/2020 - 12/2006
3Disease Progression
11/2023 - 10/2022
3Hypoxia (Hypoxemia)
10/2021 - 12/2019
3Neoplasm Metastasis (Metastasis)
01/2021 - 10/2018
3Neutropenia
01/2020 - 12/2006
3Thrombocytopenia (Thrombopenia)
12/2019 - 11/2006
3Vomiting
12/2019 - 11/2006
3Nausea
12/2019 - 11/2006
2Carcinogenesis
11/2023 - 01/2021
2Exanthema (Rash)
11/2023 - 06/2014
2Breast Neoplasms (Breast Cancer)
04/2023 - 12/2019
2Anemia
10/2020 - 01/2020
2Diarrhea
06/2014 - 12/2006
1Triple Negative Breast Neoplasms
04/2023
1Lymphopenia (Lymphocytopenia)
10/2021
1Urinary Tract Infections (Urinary Tract Infection)
10/2020
1Carcinoma (Carcinomatosis)
10/2020
1Circulating Neoplastic Cells
01/2020
1Hypersensitivity (Allergy)
12/2019
1Febrile Neutropenia
12/2019
1Dizziness (Lightheadedness)
12/2019
1Hyponatremia
12/2019
1Lung Neoplasms (Lung Cancer)
12/2019
1Pancreatic Neoplasms (Pancreatic Cancer)
12/2019
1Peripheral Nervous System Diseases (PNS Diseases)
12/2019
1Urinary Bladder Neoplasms (Bladder Cancer)
01/2019

Drug/Important Bio-Agent (IBA)

4AntigensIBA
10/2023 - 10/2013
4Biomarkers (Surrogate Marker)IBA
10/2021 - 06/2014
3belzutifanIBA
11/2023 - 01/2021
3enzalutamideIBA
11/2023 - 01/2020
3abirateroneIBA
11/2023 - 01/2020
3pembrolizumabIBA
11/2023 - 10/2020
3Sunitinib (Sutent)FDA Link
10/2023 - 12/2011
3Immune Checkpoint InhibitorsIBA
01/2022 - 10/2016
3EverolimusFDA Link
01/2019 - 10/2016
3Phosphotransferases (Kinase)IBA
10/2018 - 04/2011
2Transcription Factors (Transcription Factor)IBA
11/2023 - 01/2021
2GemcitabineFDA Link
10/2023 - 11/2006
2Paclitaxel (Taxol)FDA LinkGeneric
04/2023 - 12/2019
2Carboplatin (JM8)FDA LinkGeneric
04/2023 - 12/2019
2veliparibIBA
04/2023 - 12/2019
2VaccinesIBA
01/2023 - 08/2010
2cabozantinibIBA
10/2022 - 10/2018
2AndrogensIBA
01/2022 - 01/2021
2ElectrolytesIBA
10/2021 - 01/2020
2Radium-223IBA
01/2021 - 01/2016
2Antineoplastic Agents (Antineoplastics)IBA
05/2019 - 11/2015
2NivolumabIBA
01/2018 - 10/2016
2Methotrexate (Mexate)FDA LinkGeneric
06/2014 - 01/2014
2Cisplatin (Platino)FDA LinkGeneric
06/2014 - 01/2014
2Doxorubicin (Adriamycin)FDA LinkGeneric
06/2014 - 01/2014
2Vinblastine (Vinblastine Sulfate)FDA Link
06/2014 - 01/2014
2Sorafenib (BAY 43-9006)FDA Link
06/2014 - 04/2011
2Bortezomib (Velcade)FDA Link
12/2006 - 11/2006
1pazopanibFDA Link
03/2024
1Androgen Receptors (Androgen Receptor)IBA
11/2023
1Abiraterone AcetateIBA
11/2023
1taxaneIBA
10/2023
1cediranib (AZD2171)IBA
01/2023
1olaparibIBA
01/2023
1Hormones (Hormone)IBA
01/2023
1Glutamic Acid (Glutamate)FDA Link
10/2022
1EnzymesIBA
10/2022
1GlutaminaseIBA
10/2022
1Glutamine (L-Glutamine)FDA Link
10/2022
1HLA-A Antigens (HLA-A)IBA
01/2022
1Docetaxel (Taxotere)FDA Link
01/2022
1Prednisone (Sone)FDA LinkGeneric
01/2022
1SteroidsIBA
01/2022
1ARQ 197IBA
10/2021
1Bevacizumab (Avastin)FDA Link
10/2021
1atezolizumabIBA
01/2021
1PlatinumIBA
10/2020
1Programmed Cell Death 1 ReceptorIBA
10/2020
1Alanine Transaminase (SGPT)IBA
10/2020
1acalabrutinibIBA
10/2020
1PSMA ADCIBA
01/2020
1Prostate-Specific Antigen (Semenogelase)IBA
01/2020
1Tretinoin (Retinoic Acid)FDA LinkGeneric
12/2019
1Cytotoxins (Cytolysins)IBA
12/2019
1Histone Deacetylase InhibitorsIBA
12/2019
1Isotretinoin (Accutane)FDA LinkGeneric
12/2019
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2019
1belinostatIBA
12/2019
1Poly(ADP-ribose) Polymerase InhibitorsIBA
12/2019
1vasectrin I (VS I)IBA
01/2019
1Hydroxychloroquine (Plaquenil)FDA LinkGeneric
01/2019
1MTOR InhibitorsIBA
01/2019
1Tyrosine (L-Tyrosine)FDA Link
10/2018
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
10/2018

Therapy/Procedure

16Therapeutics
11/2023 - 12/2009
8Castration
11/2023 - 12/2010
6Immunotherapy
10/2023 - 10/2016
4Drug Therapy (Chemotherapy)
01/2022 - 01/2014
2Metastasectomy
03/2024 - 01/2018
1Nephrectomy
01/2019
1Neoadjuvant Therapy
01/2019