Vandana G Abramson Selected Research

2- (3- (2- (1- isopropyl- 3- methyl- 1H- 1,2- 4- triazol- 5- yl)- 5,6- dihydrobenzo(f)imidazo(1,2- d)(1,4)oxazepin- 9- yl)- 1H- pyrazol- 1- yl)- 2- methylpropanamide

1/2020	TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR+ Metastatic Triple-Negative Breast Cancer.
11/2019	A phase Ib, open-label, dose-escalation study of the safety and pharmacology of taselisib (GDC-0032) in combination with either docetaxel or paclitaxel in patients with HER2-negative, locally advanced, or metastatic breast cancer.

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Vandana G Abramson Research Topics

Disease

38	Breast Neoplasms (Breast Cancer) 04/2024 - 09/2011
26	Neoplasms (Cancer) 04/2024 - 01/2012
12	Triple Negative Breast Neoplasms 04/2024 - 09/2014
9	Pathologic Complete Response 11/2023 - 06/2013
5	Disease Progression 12/2023 - 03/2013
3	Neutropenia 04/2024 - 01/2012
3	Diarrhea 01/2022 - 01/2017
2	Fatigue 04/2024 - 01/2017
2	Hypertension (High Blood Pressure) 04/2024 - 01/2022
2	Lymphedema (Milroy Disease) 01/2023 - 12/2022
1	Left Ventricular Dysfunction 04/2024
1	Obesity 12/2023
1	Genomic Instability 11/2023
1	Ovarian Neoplasms (Ovarian Cancer) 11/2023
1	Residual Neoplasm 03/2023
1	Breast Cancer Lymphedema 12/2022
1	Type 2 Diabetes Mellitus (MODY) 01/2022
1	Menstruation Disturbances 01/2022
1	Hand-Foot Syndrome 06/2020
1	Dermatitis 01/2020
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2019
1	Body Weight (Weight, Body) 01/2019
1	Mucositis 08/2017
1	Hyperglycemia 01/2017
1	Nausea 01/2017
1	Exanthema (Rash) 01/2017
1	Clinical Deterioration 06/2014
1	Metabolic Diseases (Metabolic Disease) 04/2014
1	Arthralgia (Joint Pain) 07/2013

Drug/Important Bio-Agent (IBA)

7	Estrogen ReceptorsIBA 11/2023 - 04/2014
6	Biomarkers (Surrogate Marker)IBA 12/2023 - 05/2012
4	human ERBB2 proteinIBA 04/2024 - 05/2012
4	Hormones (Hormone)IBA 01/2022 - 01/2018
3	Immune Checkpoint InhibitorsIBA 04/2024 - 05/2021
3	Capecitabine (Xeloda)FDA Link 07/2023 - 01/2020
3	N-acetyltalosaminuronic acid (NAT)IBA 03/2023 - 10/2012
3	Paclitaxel (Taxol)FDA LinkGeneric 05/2021 - 08/2017
3	AlpelisibIBA 05/2021 - 01/2017
2	Trastuzumab (Herceptin)FDA Link 04/2024 - 11/2023
2	Carboplatin (JM8)FDA LinkGeneric 04/2024 - 12/2023
2	DNA (Deoxyribonucleic Acid)IBA 12/2023 - 01/2017
2	B7-H1 AntigenIBA 12/2023 - 11/2020
2	pertuzumabIBA 11/2023 - 10/2021
2	Circulating Tumor DNAIBA 03/2023 - 01/2021
2	taxaneIBA 12/2022 - 11/2019
2	130-nm albumin-bound paclitaxelIBA 01/2021 - 11/2020
2	2- (3- (2- (1- isopropyl- 3- methyl- 1H- 1,2- 4- triazol- 5- yl)- 5,6- dihydrobenzo(f)imidazo(1,2- d)(1,4)oxazepin- 9- yl)- 1H- pyrazol- 1- yl)- 2- methylpropanamideIBA 01/2020 - 11/2019
2	Aromatase InhibitorsIBA 01/2018 - 07/2013
2	Letrozole (Femara)FDA LinkGeneric 01/2017 - 04/2014
1	Bevacizumab (Avastin)FDA Link 04/2024
1	LigandsIBA 04/2024
1	atezolizumabIBA 12/2023
1	RNA (Ribonucleic Acid)IBA 12/2023
1	Blood Glucose (Blood Sugar)IBA 12/2023
1	PlatinumIBA 11/2023
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 11/2023
1	TFXIBA 03/2023
1	Cytidine Diphosphate (CDP)IBA 12/2022
1	Tamoxifen FDA LinkGeneric 01/2022
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2022
1	exemestane (Aromasin)FDA Link 01/2022
1	2,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamideIBA 01/2022
1	Fulvestrant (Faslodex)FDA Link 01/2022
1	BiguanidesIBA 01/2022
1	Estrogens (Estrogen)FDA Link 01/2022
1	Metformin (Glucophage)FDA LinkGeneric 01/2022
1	Ado-Trastuzumab EmtansineIBA 10/2021
1	copanlisibIBA 05/2021
1	gedatolisibIBA 05/2021
1	Androgen Receptors (Androgen Receptor)IBA 01/2020
1	enzalutamideIBA 01/2020
1	Proteins (Proteins, Gene)FDA Link 01/2020
1	Docetaxel (Taxotere)FDA Link 11/2019
1	sacituzumab govitecanIBA 01/2019
1	Irinotecan (Camptosar)FDA LinkGeneric 01/2019
1	Everolimus FDA Link 08/2017
1	Transaminases (Aminotransferases)IBA 08/2017
1	Cisplatin (Platino)FDA LinkGeneric 08/2017
1	XL147IBA 07/2017
1	seribantumabIBA 07/2017
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2016
1	Dihydrotachysterol (AT 10)IBA 01/2016
1	tigatuzumabIBA 06/2015
1	Monoclonal AntibodiesIBA 06/2015
1	Albumin-Bound Paclitaxel FDA Link 06/2015
1	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 06/2015
1	ErbB Receptors (EGF Receptor)IBA 04/2014
1	NVP-BKM120IBA 04/2014
1	Indicators and Reagents (Reagents)IBA 04/2014

Therapy/Procedure

27	Therapeutics 04/2024 - 05/2012
17	Drug Therapy (Chemotherapy) 04/2024 - 09/2011
10	Neoadjuvant Therapy 07/2023 - 10/2012
3	Immunotherapy 04/2024 - 11/2020
1	Segmental Mastectomy (Lumpectomy) 12/2022
1	Mastectomy (Mammectomy) 12/2022
1	Radiotherapy 12/2022
1	Adjuvant Radiotherapy 01/2020
1	Castration 01/2018
1	Ovariectomy (Oophorectomy) 01/2018
1	Adjuvant Chemotherapy 06/2016