İsmail Ünal Selected Research

Oxidants (Oxidizing Agents)

12/2023	Sodium-dependent glucose co-transporter-2 inhibitor empagliflozin exerts neuroprotective effects in rotenone-induced Parkinson's disease model in zebrafish; mechanism involving ketogenesis and autophagy.
12/2023	Panoramic dental X-ray exposure leads to oxidative stress, inflammation and apoptosis-mediated developmental defects in zebrafish embryos.
10/2023	Synthesis of salicylic acid from wintergreen oil by green chemistry overcomes its cytotoxicity in keratinocyte cells and teratogenicity in zebrafish embryos.
10/2023	Endotoxin of Porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs.
2/2023	Morphine ameliorates pentylenetetrazole-induced locomotor pattern in zebrafish embryos; mechanism involving regulation of opioid receptors, suppression of oxidative stress, and inflammation in epileptogenesis.
1/2022	Bisphenol A reveals its obesogenic effects through disrupting glucose tolerance, oxidant-antioxidant balance, and modulating inflammatory cytokines and fibroblast growth factor in zebrafish.
1/2022	Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation.

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İsmail Ünal Research Topics

Disease

9	Parkinson Disease (Parkinson's Disease) 04/2024 - 04/2019
7	Inflammation (Inflammations) 12/2023 - 06/2021
4	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2023 - 04/2019
2	Hyperglycemia 10/2023 - 01/2022
2	Mitochondrial Diseases (Mitochondrial Disease) 07/2022 - 03/2022
2	Body Weight (Weight, Body) 01/2022 - 01/2022
2	Obesity 01/2022 - 01/2022
2	Glucose Intolerance 01/2022 - 01/2022
1	Type 2 Diabetes Mellitus (MODY) 12/2023
1	Congenital Abnormalities (Deformity) 10/2023
1	Epilepsy (Aura) 02/2023
1	Neuroinflammatory Diseases 07/2022
1	Weight Gain 01/2022
1	Insulin Resistance 01/2022

Drug/Important Bio-Agent (IBA)

8	RotenoneIBA 12/2023 - 04/2019
7	AntioxidantsIBA 12/2023 - 01/2022
7	Oxidants (Oxidizing Agents)IBA 12/2023 - 01/2022
4	Neuroprotective AgentsIBA 04/2024 - 06/2020
3	Interleukin-6 (Interleukin 6)IBA 12/2023 - 01/2022
2	NeurotoxinsIBA 04/2024 - 06/2021
2	Glucose (Dextrose)FDA LinkGeneric 12/2023 - 01/2022
2	Cholinergic Agents (Cholinergics)IBA 10/2023 - 02/2023
1	2,5-dihydroxybenzoic acid (gentisic acid)IBA 04/2024
1	interleukin-21 (interleukin 21)IBA 12/2023
1	empagliflozinIBA 12/2023
1	Sodium-Glucose Transporter 2 InhibitorsIBA 12/2023
1	Hypoglycemic Agents (Hypoglycemics)IBA 12/2023
1	KetonesIBA 12/2023
1	SodiumIBA 12/2023
1	3,4-Dihydroxyphenylacetic AcidIBA 12/2023
1	Caspase 3 (Caspase-3)IBA 12/2023
1	Sirtuin 1IBA 12/2023
1	Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric 10/2023
1	Proteins (Proteins, Gene)FDA Link 10/2023
1	Gingipain Cysteine EndopeptidasesIBA 10/2023
1	EndotoxinsIBA 10/2023
1	ChitinasesIBA 10/2023
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 02/2023
1	Pentylenetetrazole (Metrazol)IBA 02/2023
1	Opioid Receptors (Opioid Receptor)IBA 02/2023
1	Morphine (MS Contin)FDA LinkGeneric 02/2023
1	LigandsIBA 01/2023
1	erucic acidIBA 01/2023
1	CalciumIBA 07/2022
1	UbiquitinIBA 07/2022
1	Rifampin (Rifampicin)FDA LinkGeneric 07/2022
1	Proteasome Endopeptidase Complex (Proteasome)IBA 07/2022
1	3-pyridinylboronic acidIBA 03/2022
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 03/2022
1	steviosideIBA 01/2022
1	Glutathione Transferase (Glutathione S-Transferase)IBA 01/2022
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2022
1	Blood Glucose (Blood Sugar)IBA 01/2022
1	fibroblast growth factor 21IBA 01/2022
1	Sweetening Agents (Sweeteners)IBA 01/2022
1	Superoxide DismutaseIBA 01/2022
1	Triglycerides (Triacylglycerol)IBA 10/2021
1	octanoic acid (caprylic acid)IBA 06/2021
1	mitoquinoneIBA 06/2020
1	oleandrinIBA 06/2020
1	Dopamine (Intropin)FDA LinkGeneric 04/2019

Therapy/Procedure

1	Ketogenic Diet 12/2023