[Value of the conjunctival provocation test in evaluating the activity of 2 concentrations of anti-allergy eyedrops, mequitazine].

Abstract

PURPOSE:

To compare the activity of topical 0.05% and 0.01% mequitazine versus vehicle in the prevention of allergic conjunctivitis induced by a conjunctival provocation test with allergens.

METHODS:

Forty subjects with a history of grass pollen allergic conjunctivitis were enrolled in this comparative, randomized, double-masked study. Fifteen minutes before the conjunctival provocation test, subjects received one instillation alone of 0.05% mequitazine eyedrops in one eye and in the fellow eye either one drop of 0.01% dose or vehicle, at the same dosage. Then a specific conjunctival provocation test (CPT) was performed with the allergen threshold concentration previously defined. The therapeutic efficacy was assessed by the decrease in a symptomatic composite score representing the allergic reaction.

RESULTS:

Topical mequitazine at the dose of 0.05% significantly decreases the intensity of the allergic reaction compared to vehicle. Moreover, the group treated with this dose needed a higher allergen concentration to trigger ocular signs. The 0.01% dose appears efficient only on itching, compared to vehicle.

CONCLUSION:

The results of this study support the efficacy and the onset of action of 0.05% mequitazine eyedrops versus 0.01% or vehicle in the prevention of allergic conjunctivitis induced by a conjunctival provocation test.

• Authors: O Dupin, S Compeyre, C Trinquand, L Persi, B Arnaud
• Journal: Journal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 21 Issue 1 Pg. 12-8 (Jan 1998) ISSN: 0181-5512 [Print] France
• Vernacular Title: Intérêt du Test de Provocation Conjonctivale (TPC) dans l'évaluation de l'activité de deux concentrations d'un collyre anti-allergique, la méquitazine.
• PMID: 9834894 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Allergens
• Histamine H1 Antagonists
• Ophthalmic Solutions
• Phenothiazines
• mequitazine

Topics

• Adult
• Allergens
• Conjunctivitis, Allergic (diagnosis, drug therapy)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Female
• Histamine H1 Antagonists (administration & dosage, adverse effects)
• Humans
• Male
• Ophthalmic Solutions
• Phenothiazines (administration & dosage, adverse effects)
• Treatment Outcome