Similar cytogenetic effects of sodium-meglumine diatrizoate and sodium-meglumine ioxithalamate in lymphocytes of patients undergoing brain CT scan.

Abstract

Cytogenetic effects of two ionic contrast media (CM), Urografin 76% a sodium-meglumine diatrizoate, and Telebrix 38, a sodium-meglumine ioxythalamate, were tested on lymphocytes of patients undergoing brain CT Scan. Both compounds have approximately similar iodine concentrations. Chromosomal aberrations were scored in peripheral lymphocytes obtained from 15 patients undergoing brain CT with either urografin 76% or telebrix 38 before and after examination. Results showed no difference in aberration frequency for patients who underwent brain CT without contrast materials compared to controls. However, injection of CM resulted in a high frequency of chromosomal aberrations which significantly differed from controls (P < 0.05). The effect of urografin 76% appeared to be similar to telebrix 38. Therefore, both CM exhibited clastogenic effects on peripheral lymphocytes in vivo. An increase in chromosomal aberrations due to CM used in this study were similar to that reported for other ionic and non-ionic compounds.

• Authors: H Mozdarani, S Fadaei
• Journal: Toxicology letters (Toxicol Lett) Vol. 98 Issue 1-2 Pg. 25-30 (Sep 01 1998) ISSN: 0378-4274 [Print] Netherlands
• PMID: 9776558 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Diatrizoate
• Iothalamic Acid
• ioxitalamic acid

Topics

• Adolescent
• Adult
• Brain (diagnostic imaging)
• Cells, Cultured
• Chromatids (drug effects, ultrastructure)
• Chromosome Aberrations
• Contrast Media (adverse effects)
• Diatrizoate (adverse effects)
• Female
• Humans
• Iothalamic Acid (adverse effects, analogs & derivatives)
• Lymphocytes (drug effects, ultrastructure)
• Male
• Middle Aged
• Tomography, X-Ray Computed (adverse effects)