Abstract | BACKGROUND: METHODS: Six hundred patients with seasonal allergic rhinitis were treated for 2 weeks with either FP ANS 200 microgram once daily, loratadine 10 mg once daily, the FP ANS and loratadine regimens combined, or placebo in a multicenter, randomized, double-blind, double-dummy, parallel-group study. RESULTS: Clinician- and patient-rated total and individual nasal symptom scores after 7 and 14 days of therapy and overall evaluations were significantly lower (P < .001) in the FP ANS and FP ANS plus loratadine groups compared with the loratadine only and placebo groups. Loratadine was not statistically different from placebo in clinician and patient symptom score ratings nor in overall clinician and patient evaluations. FP ANS plus loratadine and FP ANS monotherapy were comparable in efficacy in almost all evaluations; for some patient-rated symptoms the combination was found superior. Mean score changes in the Rhinoconjunctivitis Quality of Life Questionnaire from baseline to day 14 showed significantly greater improvement (P < .001) in quality of life in the FP ANS group than in the group of patients receiving loratadine only or placebo and no significant benefit was demonstrated in the FP ANS plus loratadine group over the FP ANS monotherapy group. No serious or unusual drug-related adverse events were reported. Combining loratadine with FP ANS did not alter the adverse events profile or frequency.
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Authors | P H Ratner, J H van Bavel, B G Martin, F C Hampel Jr, W C Howland 3rd, P R Rogenes, R E Westlund, B W Bowers, C K Cook |
Journal | The Journal of family practice
(J Fam Pract)
Vol. 47
Issue 2
Pg. 118-25
(Aug 1998)
ISSN: 0094-3509 [Print] United States |
PMID | 9722799
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androstadienes
- Anti-Inflammatory Agents
- Drug Combinations
- Glucocorticoids
- Histamine H1 Antagonists
- Loratadine
- Fluticasone
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Topics |
- Administration, Intranasal
- Adolescent
- Adult
- Aged
- Androstadienes
(therapeutic use)
- Anti-Inflammatory Agents
(therapeutic use)
- Double-Blind Method
- Drug Combinations
- Female
- Fluticasone
- Glucocorticoids
- Histamine H1 Antagonists
(therapeutic use)
- Humans
- Loratadine
(therapeutic use)
- Male
- Middle Aged
- Pollen
(immunology)
- Quality of Life
- Rhinitis, Allergic, Seasonal
(drug therapy, immunology)
- Texas
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