[Myofibroblastic tumors. Brief review of clinical aspects, diagnosis and differential diagnosis].

Abstract

This review summarizes myofibroblastic tumours that have been characterized in the last years. These lesions include: fibromatoses in adults and infants (infantile digital fibromatosis and infantile myofibromatosis); myofibroma of adults, an almost exclusively solitary lesion in the skin which is characterized morphologically as a biphasic lesion composed of spindle-shaped eosinophilic tumour cells and more primitive mesenchymal tumour cells associated with a haemangiopericytoma-like vasculature; dermatomyofibroma (plaque-like dermal fibromatosis), a band-like myofibroblastic proliferation in young female patients, which is mainly located in the periaxillar region and in which distinction from more aggressive, plaque-like variant of dermatofibrosarcoma protuberans is mandatory; myofibroblastoma of the breast, a well-circumscribed lesion composed of spindle shaped, desmin-positive tumour cells, which is seen mainly in elderly male patients and has to be distinguished from other spindle cell lesions of the breast; angiomyofibroblastoma, a well-circumscribed myofibroblastic neoplasm of the vulva and vagina composed of avoid to round myoid tumour cells with scattered multinucleated cells, which forms a continuous morphological spectrum with the clinically more aggressive angiomyxoma in this location; intranodal myofibroblastoma, a distinctive proliferation of myofibroblastic cells associated with so-called amianthoid fibres, which is seen most commonly in inguinal lymph nodes; myofibroblastoma/myofibroblastic tumour of soft tissues, a variably well-circumscribed myofibroblastic lesion which lacks atypia and is composed of actin and/or desmin positive tumour cells, and poorly delineated sarcomas with myofibroblastic differentiation (myofibrosarcoma).

• Authors: T Mentzel, D Katenkamp
• Journal: Der Pathologe (Pathologe) Vol. 19 Issue 3 Pg. 176-86 (May 1998) ISSN: 0172-8113 [Print] Germany
• Vernacular Title: Myofibroblastäre Tumoren. Kurzgefasste Ubersicht zur Klinik, Diagnose und Differentialdiagnose.
• PMID: 9648142 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Biomarkers, Tumor

Topics

• Adult
• Biomarkers, Tumor (analysis)
• Child
• Diagnosis, Differential
• Female
• Fibromatosis, Aggressive (pathology)
• Humans
• Infant
• Leiomyoma (pathology)
• Lymph Nodes (pathology)
• Male
• Myofibromatosis (pathology)
• Skin Neoplasms (pathology)
• Soft Tissue Neoplasms (pathology)