Lhermitte's sign following chemotherapy with docetaxel.

Abstract

Specific causes for Lhermitte's sign (LS) in cancer patients are spinal cord compression, radiation therapy to the spinal cord, and cisplatin chemotherapy. We observed a transient LS in five of 87 patients treated with more than two cycles of 100 mg/m2 docetaxel (Taxotere). LS developed either concurrently or after the onset of docetaxel-induced sensory neuropathy, and disappeared after the discontinuation or dose reduction of chemotherapy.

• Authors: M J van den Bent, P H Hilkens, P A Sillevis Smitt, V J van Raaij-van den Aarssen, M Bontenbal, J Verweij
• Journal: Neurology (Neurology) Vol. 50 Issue 2 Pg. 563-4 (Feb 1998) ISSN: 0028-3878 [Print] United States
• PMID: 9484402 (Publication Type: Case Reports, Clinical Trial, Clinical Trial, Phase II, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Taxoids
• Docetaxel
• Paclitaxel

Topics

• Adult
• Antineoplastic Agents, Phytogenic (administration & dosage, adverse effects)
• Docetaxel
• Female
• Humans
• Infusions, Intravenous
• Magnetic Resonance Imaging
• Middle Aged
• Neoplasms (drug therapy)
• Paclitaxel (administration & dosage, adverse effects, analogs & derivatives)
• Spinal Cord (pathology)
• Spinal Cord Diseases (chemically induced, diagnosis)
• Taxoids