The farnesyltransferase inhibitor, FPT inhibitor III upregulates Bax and Bcl-xs expression and induces apoptosis in human ovarian cancer cells.

Abstract	Deregulation in the ras oncogene is a common event in many types of human cancer. Our previous study clearly demonstrated that genetic alterations of ras oncogene are frequently found in human epithelial ovarian cancer. Recent reports have indicated that farnesyltransferase is involved in the regulation of post-translational modification and biological function of Ras proteins. Here, we report that a newly synthesized farnesyltransferase inhibitor, FPT inhibitor III, upregulates Bax and Bcl-xs expression and induces apoptosis in human ovarian cancer cells. This is a critical finding that farnesyltransferase inhibitors may directly activate apoptotic signaling pathways in cancer cells and may help to provide a new strategy in the treatment of human cancer.
Authors	W C Hung, L Y Chaung
Journal	International journal of oncology (Int J Oncol) Vol. 12 Issue 1 Pg. 137-40 (Jan 1998) ISSN: 1019-6439 [Print] Greece
PMID	9454897 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	BAK1 protein, human BAX protein, human BCL2L1 protein, human Chromatin Enzyme Inhibitors Membrane Proteins Polyisoprenyl Phosphates Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Sesquiterpenes bcl-2 Homologous Antagonist-Killer Protein bcl-2-Associated X Protein bcl-X Protein farnesyl pyrophosphate Alkyl and Aryl Transferases Farnesyltranstransferase
Topics	Alkyl and Aryl Transferases (antagonists & inhibitors, metabolism) Apoptosis (drug effects) Blotting, Western Cell Division (drug effects) Chromatin (chemistry) Dose-Response Relationship, Drug Enzyme Inhibitors (pharmacology) Farnesyltranstransferase Female Humans Membrane Proteins (metabolism) Ovarian Neoplasms (enzymology, pathology) Polyisoprenyl Phosphates (pharmacology) Proto-Oncogene Proteins (metabolism) Proto-Oncogene Proteins c-bcl-2 (metabolism) Sesquiterpenes Tumor Cells, Cultured (drug effects) Up-Regulation bcl-2 Homologous Antagonist-Killer Protein bcl-2-Associated X Protein bcl-X Protein

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!