Increased resistance to Taenia crassiceps murine cysticercosis in Qa-2 transgenic mice.

Abstract

We previously reported important differences in resistance to Taenia crassiceps murine cysticercosis between BALB/c substrains. It was suggested that resistance might correlate with expression of the nonclassic class I major histocompatibility complex (MHC) Qa-2 antigen; BALB/cAnN is Qa-2 negative and highly susceptible to T. crassiceps, whereas BALB/cJ expresses Qa-2 and is highly resistant. In this study, we investigated the role of Qa-2 in mediating resistance to cysticercosis by linkage analysis and infection of Qa-2 transgenic mice. In BALB/cAnN x (C57BL/6J x BALB/cAnN)F1 and BALB/cAnN x (BALB/cJ x BALB/cAnN)F1 backcrosses, the expression of Qa-2 antigen correlated with resistance to cysticercosis. Significantly fewer parasites were recovered from infected Qa-2 transgenic male and female mice than from nontransgenic mice of similar genetic background. These results clearly demonstrate that the Qa-2 MHC antigen is involved in resistance to T. crassiceps cysticercosis.

• Authors: G Fragoso, E Lamoyi, A Mellor, C Lomelí, M Hernández, E Sciutto
• Journal: Infection and immunity (Infect Immun) Vol. 66 Issue 2 Pg. 760-4 (Feb 1998) ISSN: 0019-9567 [Print] United States
• PMID: 9453638 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Histocompatibility Antigens Class I
• Q surface antigens

Topics

• Animals
• Cysticercosis (immunology)
• Female
• Histocompatibility Antigens Class I (genetics, physiology)
• Male
• Mice
• Mice, Inbred Strains
• Mice, Transgenic
• Sex Factors
• Species Specificity