Distribution and photodynamic effect of zinc phthalocyanine disulfonate in nude mice bearing mammary carcinoma.

Abstract

The distribution study of zinc phthalocyanine disulfonate (ZnPcS2) in nude mice bearing mammary carcinoma (T50/80) revealed a rapid uptake of the dye by tumor. In experimental photodynamic therapy (PDT), the tumors were exposed to laser radiation (670 nm, 100 mW/cm2, 150 J/ /cm2) after intravenous administration of ZnPcS2 in saline. The results showed the maximum tumor destruction to be achieved for the time interval between injection of the drug (2 mg/kg) and exposure to laser light of 5 min, while a significantly less damage was observed when the time interval was 24 h (p < 0.0001). The degree of damage produced by the treatment was monitored in vivo by means of noninvasive NMR-imaging and subsequently confirmed histologically.

• Authors: M Mosa, M Zitko, P Poucková
• Journal: Neoplasma (Neoplasma) Vol. 44 Issue 3 Pg. 178-83 ( 1997) ISSN: 0028-2685 [Print] Slovakia
• PMID: 9372860 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Indoles
• Organometallic Compounds
• Photosensitizing Agents
• zinc phthalocyanine disulfonate

Topics

• Animals
• Female
• Indoles (pharmacokinetics, pharmacology)
• Magnetic Resonance Imaging
• Mammary Neoplasms, Experimental (drug therapy, metabolism)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Necrosis
• Organometallic Compounds (pharmacokinetics, pharmacology)
• Photochemotherapy
• Photosensitizing Agents (pharmacokinetics)
• Tissue Distribution