The characteristic gene expressions of MAPK phosphatases 1 and 2 in hepatocarcinogenesis, rat ascites hepatoma cells, and regenerating rat liver.

Abstract	mRNA levels of mitogen-activated protein kinase phosphatases, MKP-1 and MKP-2, were determined during chemical hepatocarcinogenesis and during regeneration of rat liver. In chemical hepatocarcinogenesis, the mRNA levels of MKP-1 were increased in primary hepatomas but decreased in rat ascites hepatomas as compared with normal liver. MKP-2 was undetectable in normal liver but strongly expressed in hepatomas. The MKP-2 mRNA level was increased with expression of malignant phenotypes in hepatomas. In regenerating liver, the mRNA level of MKP-1 increased immediately but transiently after partial hepatectomy, and peaked again on day 10, the time when hepatocytes cease proliferation. The elevated expression of MKP-1 on day 10 suggests some roles of MKP-1 as a negative regulator in hepatocyte proliferation.
Authors	A Yokoyama, H Karasaki, N Urushibara, K Nomoto, Y Imai, K Nakamura, Y Mizuno, K Ogawa, K Kikuchi
Journal	Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 239 Issue 3 Pg. 746-51 (Oct 29 1997) ISSN: 0006-291X [Print] United States
PMID	9367840 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Cell Cycle Proteins Immediate-Early Proteins RNA, Messenger Mitogen-Activated Protein Kinase Phosphatases Phosphoprotein Phosphatases Protein Phosphatase 1 Dual Specificity Phosphatase 1 Dual-Specificity Phosphatases Dusp1 protein, rat Dusp4 protein, rat Protein Tyrosine Phosphatases
Topics	Animals Ascites (enzymology, genetics, pathology) Carcinoma, Hepatocellular (enzymology, genetics, pathology) Cell Cycle Proteins Cell Division (genetics) Dual Specificity Phosphatase 1 Dual-Specificity Phosphatases Gene Expression Regulation, Neoplastic Immediate-Early Proteins (biosynthesis, genetics) Liver Neoplasms, Experimental (enzymology, genetics, pathology) Liver Regeneration (genetics) Male Mitogen-Activated Protein Kinase Phosphatases Phosphoprotein Phosphatases Protein Phosphatase 1 Protein Tyrosine Phosphatases (biosynthesis, genetics) RNA, Messenger (biosynthesis) Rats Rats, Wistar

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