Pro- and anti-oxidant parameters in rat liver after short-term exposure to hexachlorobenzene.

Abstract

The association between an in vivo oxidative stress condition of the liver and hepatic porphyria during HCB intoxication is postulated. After 30 days of treatment, HCB (25 mg/kg b.w.) promotes an induction of microsomal cytochrome P450 system, increase in microsomal superoxide anion generation accompanied by increased levels of liver lipid peroxidation, as measured by the production of thiobarbituric acid reactants and by spontaneous visible chemiluminescence. Concomitantly, liver antioxidant defenses are slightly modified, with decreased activity of glutathione peroxidase, superoxide dismutase and glucose-6-phosphate dehydrogenase contributing to an oxidative stress condition of the liver. These liver biochemical alterations are closely related to increased levels of urinary coproporphyrin, plasma AST and ALT activities and to the onset of liver morphological lesions.

• Authors: M G Almeida, F Fanini, S C Davino, A E Aznar, O R Koch, S B Barros
• Journal: Human & experimental toxicology (Hum Exp Toxicol) Vol. 16 Issue 5 Pg. 257-61 (May 1997) ISSN: 0960-3271 [Print] England
• PMID: 9192204 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Coproporphyrins
• Fungicides, Industrial
• Hexachlorobenzene
• Cytochrome P-450 Enzyme System
• Glutathione Peroxidase

Topics

• Animals
• Coproporphyrins (urine)
• Cytochrome P-450 Enzyme System (metabolism)
• Erythrocytes (drug effects)
• Fungicides, Industrial (toxicity)
• Glutathione Peroxidase (metabolism)
• Hexachlorobenzene (toxicity)
• Liver (drug effects, metabolism)
• Male
• Oxidative Stress
• Porphyrias (chemically induced, metabolism)
• Rats
• Rats, Wistar