Abstract | BACKGROUND: CASE REPORT: RESULTS: Blood samples obtained on Days 28 and 56 after the last injection were tested for carboplatin-dependent antibody. The direct antiglobulin test was 1+ with anti-IgG; the eluate was 1+ with and without carboplatin. The serum indirect antiglobulin test was negative in the absence of carboplatin, 3+ to 4+ in the presence of carboplatin, and 1+ with carboplatin-coated cells. Day 56 serum antibody titer was 64 (agglutination at 37 degrees C), 512 (indirect antiglobulin test) in the presence of carboplatin, and 8 (indirect antiglobulin test) with carboplatin-coated cells. CONCLUSION:
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Authors | T M Marani, M B Trich, K S Armstrong, P M Ness, J Smith, C Minniti, S G Sandler |
Journal | Transfusion
(Transfusion)
1996 Nov-Dec
Vol. 36
Issue 11-12
Pg. 1016-8
ISSN: 0041-1132 [Print] United States |
PMID | 8937414
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Autoantibodies
- Carboplatin
- Cisplatin
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Topics |
- Anemia, Hemolytic, Autoimmune
(chemically induced, immunology)
- Antineoplastic Agents
(administration & dosage, adverse effects, immunology, therapeutic use)
- Astrocytoma
(drug therapy)
- Autoantibodies
(immunology)
- Brain Neoplasms
(drug therapy)
- Carboplatin
(administration & dosage, adverse effects, immunology, therapeutic use)
- Child
- Cisplatin
(immunology)
- Humans
- Injections, Intravenous
- Male
- Neurofibromatoses
(drug therapy)
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