The immunopathology of Guillain-Barré syndrome.

Abstract

Identification of new antigens in different patterns of Guillain-Barré syndrome has led to new pathophysiological concepts of Guillain-Barré syndrome and the related Miller-Fisher syndrome. Patients with Guillain-Barré syndrome occurring after Campylobacter jejuni infection have been found to develop more frequently axonal and motor forms of the syndrome. Anti-GM1 antibodies decreased Na+ current in the presence of complement. In acute axonal Guillain-Barré syndrome, macrophages were found in the periaxonal space without damaging myelin sheath. Important epitopes may be localized on the axolemma, but further studies are needed to confirm these observations.

• Authors: K Saida
• Journal: Current opinion in neurology (Curr Opin Neurol) Vol. 9 Issue 5 Pg. 329-33 (Oct 1996) ISSN: 1350-7540 [Print] England
• PMID: 8894406 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies
• Epitopes
• HLA Antigens

Topics

• Animals
• Antibodies (analysis)
• Axons (immunology, ultrastructure)
• Campylobacter Infections (complications)
• Epitopes (analysis)
• HLA Antigens (analysis)
• Humans
• Polyradiculoneuropathy (immunology, pathology)
• T-Lymphocytes (immunology)