The effects of mesoporphyrin on experimental arthritis in mice.

Abstract	The effects of mesoporphyrin, a novel porphyrin derivative, on type II collagen-induced arthritis in mice were studied. Mesoporphyrin (10-30 mg/kg) and prednisolone (5 mg/kg; reference drug) reduced the incidence and severity of type II collagen-induced arthritis in mice, as assayed by clinical observation and histopathological studies. Although both agents inhibited type II collagen-induced delayed type hypersensitivity in arthritic mice, only prednisolone inhibited humoral immunity to type II collagen. The effects of mesoporphyrin on T cell dependent allergic inflammation were examined, in order to study the mechanism by which it inhibits arthritis. Staphylococcal enterotoxin B (SEB; superantigen)-potentiated collagen-induced arthritis and sheep red blood cell-induced delayed type hypersensitivity reaction were clearly inhibited by mesoporphyrin. Moreover, the superantigen-induced CD-25 expression on T cells was inhibited by mesoporphyrin. These results indicate that mesoporphyrin inhibits type II collagen-induced arthritis by inhibiting the activation of T cells.
Authors	H Nagai, Y Takaoka, H Mori, N Matsuura
Journal	Inflammation research : official journal of the European Histamine Research Society ... [et al.] (Inflamm Res) Vol. 45 Issue 6 Pg. 293-8 (Jun 1996) ISSN: 1023-3830 [Print] Switzerland
PMID	8814461 (Publication Type: Journal Article)
Chemical References	CD4 Antigens Enterotoxins Mesoporphyrins Receptors, Interleukin-2 Superantigens mesoporphyrin IX Collagen Prednisolone
Topics	Animals Arthritis (chemically induced, drug therapy) CD4 Antigens (biosynthesis, genetics) Collagen (administration & dosage, toxicity) Disease Models, Animal Enterotoxins (administration & dosage, toxicity) Hypersensitivity, Delayed Lymphocyte Activation (drug effects) Male Mesoporphyrins (administration & dosage, pharmacology, therapeutic use) Mice Mice, Inbred DBA Prednisolone (administration & dosage, pharmacology, therapeutic use) Receptors, Interleukin-2 (biosynthesis, genetics) Reference Standards Staphylococcus (metabolism) Superantigens (toxicity) T-Lymphocytes (cytology, drug effects)

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