Abstract | OBJECTIVE: To determine plasma concentrations of steroid hormones in ferrets with hyperadrenocorticism associated with adrenocortical neoplasia or nodular hyperplasia of the adrenal gland, the effect of surgical removal of the affected adrenal gland on concentrations of these hormones, and whether any hormone concentrations could be used as a marker for the disease. DESIGN: Prospective case series. ANIMALS: PROCEDURE: RESULTS: Median plasma concentrations of 17-hydroxyprogesterone, androstenedione, and dehydroepiandrosterone sulfate were significantly higher in ferrets with adrenal gland disease, compared with concentrations in clinically normal ferrets. After adrenalectomy, median concentrations of estradiol, 17-hydroxyprogesterone, and androstenedione decreased significantly. Of 23 ferrets in which concentrations of estradiol, 17-hydroxyprogesterone, and androstenedione all were measured, 22 (96%) had high concentrations of at least 1 of these 3 hormones, but only 5 (22%) ferrets had high concentrations of all 3 hormones. CLINICAL IMPLICATIONS:
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Authors | K L Rosenthal, M E Peterson |
Journal | Journal of the American Veterinary Medical Association
(J Am Vet Med Assoc)
Vol. 209
Issue 6
Pg. 1097-102
(Sep 15 1996)
ISSN: 0003-1488 [Print] United States |
PMID | 8800255
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androgens
- Biomarkers
- Estrogens
- Testosterone
- Androstenedione
- Progesterone
- Estradiol
- Dehydroepiandrosterone Sulfate
- 17-alpha-Hydroxyprogesterone
- Hydrocortisone
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Topics |
- 17-alpha-Hydroxyprogesterone
(blood)
- Adrenal Cortex Neoplasms
(complications, veterinary)
- Adrenal Glands
(pathology)
- Adrenalectomy
(veterinary)
- Adrenocortical Hyperfunction
(blood, etiology, veterinary)
- Androgens
(blood)
- Androstenedione
(blood)
- Animals
- Biomarkers
(blood)
- Dehydroepiandrosterone Sulfate
(blood)
- Estradiol
(blood)
- Estrogens
(blood)
- Female
- Ferrets
- Hydrocortisone
(blood)
- Hyperplasia
(complications, veterinary)
- Male
- Progesterone
(blood)
- Prospective Studies
- Testosterone
(blood)
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