Effect of M-711 on experimental asthma in rats.

Abstract

We experimentally demonstrated the anti-asthmatic effects of M-711, the dry extract of a Chinese herb medicine called Mokuboi-to, using the rat model of allergic asthma. Allergic asthma was induced by the antigen-antibody reaction in the rats and they showed anaphylactic symptoms accompanied with hypotension and depression of respiratory function. More than 20 mg/kg body weight of M-711 was effective in relieving the asthmatic symptoms like methylephedrine. It could lessened the suppress of respiration and provided a good improvement. It also reduced a drop of the blood pressure and improved it quickly. Its ingredients alone were much less effective than M-711 as the total. Those data suggested that M-711 was effective for alleviating allergic asthma in the present study and that its action was provided by interaction of all ingredient raw herbs of M-711.

• Authors: K Shichinohe, M Shimizu, K Kurokawa
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 58 Issue 1 Pg. 55-9 (Jan 1996) ISSN: 0916-7250 [Print] Japan
• PMID: 8645757 (Publication Type: Journal Article)

Chemical References

• Anti-Asthmatic Agents
• Drugs, Chinese Herbal
• Plant Extracts
• moku-boi-to
• Ovalbumin
• Calcium Sulfate

Topics

• Animals
• Anti-Asthmatic Agents (pharmacology)
• Asthma (physiopathology, therapy)
• Blood Pressure (drug effects)
• Bronchitis (veterinary)
• Calcium Sulfate
• Cinnamomum zeylanicum
• Dog Diseases
• Dogs
• Drugs, Chinese Herbal (pharmacology)
• Hypersensitivity (physiopathology, therapy)
• Medicine, Chinese Traditional
• Ovalbumin (immunology)
• Panax
• Phytotherapy
• Plant Extracts (pharmacology)
• Plants, Medicinal
• Rats
• Respiratory Function Tests
• Time Factors