Abstract | OBJECTIVES: BACKGROUND: METHODS: RESULTS: An intravenous infusion of adenosine at 0.15 mg/kg body weight per min attenuated by 50% the elevation of left ventricular dP/dtmax by isoproterenol (0.075 microgram/kg per min). The same dose of adenosine infused for 15 min before ischemia significantly improved the postischemic recovery of the thickening fraction, and the thickening fraction at 30 min reperfusion was 76.8 +/- 3.3% (mean +/- SE) of the baseline value, which was significantly higher than the control value (42.9 +/- 4.5%). The relation between thickening fraction and systolic left ventricular pressure after reperfusion was shifted toward higher thickening fraction by adenosine. This beneficial effect of adenosine was not detected in rabbits given 8-phenyltheophylline before adenosine, and 8-phenyltheophylline-treated rabbits showed a time course of thickening fraction similar to that in the control group. CONCLUSIONS:
|
Authors | T Ogawa, T Miura, K Shimamoto, O Iimura |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 27
Issue 1
Pg. 225-33
(Jan 1996)
ISSN: 0735-1097 [Print] United States |
PMID | 8522700
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Cardiotonic Agents
- Cardiovascular Agents
- Lactates
- Receptors, Purinergic P1
- Adenosine Triphosphate
- Theophylline
- 8-phenyltheophylline
- Adenylyl Cyclases
- Adenosine
- Isoproterenol
|
Topics |
- Adenosine
(pharmacology)
- Adenosine Triphosphate
(metabolism)
- Adenylyl Cyclases
(drug effects)
- Analysis of Variance
- Animals
- Cardiotonic Agents
(pharmacology)
- Cardiovascular Agents
(pharmacology)
- Hemodynamics
(drug effects)
- Humans
- Infusions, Intravenous
- Isoproterenol
(pharmacology)
- Lactates
(metabolism)
- Male
- Myocardial Reperfusion
- Myocardial Stunning
(physiopathology, prevention & control)
- Myocardium
(metabolism)
- Rabbits
- Receptors, Purinergic P1
(drug effects, physiology)
- Theophylline
(analogs & derivatives, pharmacology)
|