Serum transferrin as a prognostic indicator of spontaneous closure and mortality in gastrointestinal cutaneous fistulas.
Abstract | OBJECTIVE: This study determined whether there are any laboratory or other features that will enable prediction of spontaneous closure in patients with gastrointestinal cutaneous fistulas. SUMMARY BACKGROUND DATA: Although the anatomic criteria for spontaneous closure of gastrointestinal cutaneous fistulas have been presented by several authors, less than 50% of such fistulas tend to close, even in the most recent series. METHODS: RESULTS: CONCLUSIONS: Serum transferrin does not appear to be an entirely independent variable, but seems to identify those patients with significant remote sepsis, systemic sepsis, and neoplasia in whom these processes are clinically significant. The results, if confirmed, and provided that nutritional needs are met, suggest that short-turnover proteins, particularly serum transferrin, might be useful in predicting which patients with gastrointestinal cutaneous fistulas should undergo surgery despite anatomic criteria favorable for spontaneous closure.
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Authors | B W Kuvshinoff, R J Brodish, D W McFadden, J E Fischer |
Journal | Annals of surgery
(Ann Surg)
Vol. 217
Issue 6
Pg. 615-22; discussion 622-3
(Jun 1993)
ISSN: 0003-4932 [Print] United States |
PMID | 8507110
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anastomosis, Surgical
(adverse effects)
- Bacterial Infections
- Drainage
- Female
- Fistula
(blood, etiology, physiopathology, surgery)
- Forecasting
- Gastric Fistula
(blood, etiology, physiopathology, surgery)
- Humans
- Intestinal Fistula
(blood, etiology, physiopathology, surgery)
- Male
- Middle Aged
- Parenteral Nutrition, Total
- Postoperative Complications
- Prognosis
- Retrospective Studies
- Skin Diseases
(blood, etiology, physiopathology, surgery)
- Transferrin
(analysis)
- Wound Healing
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