Tumor imaging with technetium-99m-DTPA encapsulated in RES-avoiding liposomes.

Abstract

For passive targeting of liposomes to tumor tissues, we earlier developed reticuloendothelial system (RES)-avoiding liposomes modified with a uronic acid derivative, palmityl-D-glucuronide (PGlcUA). In the present study, we encapsulated technetium-99m (99mTc)-diethylenetriaminepentaacetic acid (DTPA) in PGlcUA-liposomes (dipalmitoylphosphatidylcholine:cholesterol:PGlcUA = 40:40:20 as a molar ratio) and studied the biodistribution of the liposomes in tumor-bearing mice. 99mTc-DTPA encapsulated in liposomes effectively accumulated in tumor tissues after intravenous administration. Corresponding to these results, tumor was strongly imaged by a gamma-camera when 99mTc-DTPA-encapsulated PGlcUA-liposomes were used.

• Authors: N Oku, Y Namba, A Takeda, S Okada
• Journal: Nuclear medicine and biology (Nucl Med Biol) Vol. 20 Issue 4 Pg. 407-12 (May 1993) ISSN: 0969-8051 [Print] United States
• PMID: 8504283 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Drug Carriers
• Liposomes
• Phosphatidylglycerols
• 1,2-Dipalmitoylphosphatidylcholine
• 1,2-dipalmitoylphosphatidylglycerol
• Technetium Tc 99m Pentetate

Topics

• 1,2-Dipalmitoylphosphatidylcholine
• Animals
• Drug Carriers
• Gamma Cameras
• Injections, Intravenous
• Liposomes
• Male
• Mice
• Mice, Inbred Strains
• Mononuclear Phagocyte System (metabolism)
• Phosphatidylglycerols
• Radionuclide Imaging
• Sarcoma 180 (diagnostic imaging, metabolism)
• Technetium Tc 99m Pentetate (administration & dosage, pharmacokinetics)
• Tissue Distribution