Single dose quinolone treatment in acute uncomplicated urinary tract infection in women.

Abstract

A total of 125 ambulatory women (85 premenopausal and 40 postmenopausal) who experienced 174 acute urinary tract infections with mainly gram-negative bacteria (99%) was randomized to receive a single dose, 2-tablet treatment with either ofloxacin (400 mg.), norfloxacin (800 mg.) or ciprofloxacin (500 mg.). Cure was achieved in 163 of the 174 acute episodes (94%). More specifically, the cure rates were 97% (57 of 59 infections) with ofloxacin, 96.5% (56 of 58) with ciprofloxacin and 88% (50 of 57) with norfloxacin. While the initial cure rate of the acute urinary tract infections was 96% (112 of 117) in the premenopausal group, it reached only 90% (51 of 57) in the postmenopausal group. The 17 urinary tract infections that followed the initial 2-tablet quinolone treatment were cured by either an additional single dose, 2-tablet treatment with a different quinolone in 6 cases, a 1-day treatment with other adequate antibacterials in 9 and a 7-day treatment in 2. The 2-tablet quinolone treatment proved to be an effective, easy and cost-effective treatment for acute urinary tract infections in premenopausal and postmenopausal women.

• Authors: A Pfau, T G Sacks
• Journal: The Journal of urology (J Urol) Vol. 149 Issue 3 Pg. 532-4 (Mar 1993) ISSN: 0022-5347 [Print] United States
• PMID: 8437256 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Ciprofloxacin
• Ofloxacin
• Norfloxacin

Topics

• Acute Disease
• Adult
• Aged
• Aged, 80 and over
• Ciprofloxacin (administration & dosage, therapeutic use)
• Female
• Gram-Negative Bacterial Infections (drug therapy, microbiology)
• Humans
• Menopause
• Middle Aged
• Norfloxacin (administration & dosage, therapeutic use)
• Ofloxacin (administration & dosage, therapeutic use)
• Prospective Studies
• Urinary Tract Infections (drug therapy, microbiology)