Retrospective analysis of prognostic significance of the estrogen-inducible pS2 gene in male breast carcinoma.

Abstract

BACKGROUND:

The estrogen-inducible pS2 gene, originally isolated from a breast cancer cell line, is correlated with hormone-dependent female breast tumors and its expression is associated with longer overall and disease-free survival.

METHODS:

The authors have investigated 38 samples of carcinomas of the male breast for pS2 expression by using a monoclonal antibody. The immunostaining was compared with clinical data, in particular, to the progesterone receptor status, to assess a possible prognostic value of this parameter.

RESULTS:

Although most cases (27 of 38) were immunopositive (i.e., above the 5th percentile of immunoreactive cells), no correlation with tumor grade and survival was notable.

CONCLUSIONS:

Therefore, on the contrary to the situation in female breast cancer, pS2 activity failed to constitute a new prognostic parameter in male breast carcinomas.

• Authors: I Kardaś, G Seitz, J Limon, A Niezabitowski, J Ryś, B Theisinger, C Welter, N Blin
• Journal: Cancer (Cancer) Vol. 72 Issue 5 Pg. 1652-6 (Sep 01 1993) ISSN: 0008-543X [Print] United States
• PMID: 8394203 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Estrogens
• Neoplasm Proteins
• Proteins
• RNA, Messenger
• Receptors, Estrogen
• TFF1 protein, human
• Trefoil Factor-1
• Tumor Suppressor Proteins

Topics

• Adult
• Aged
• Biomarkers, Tumor (analysis, genetics)
• Breast Neoplasms (genetics)
• Carcinoma (genetics)
• Carcinoma, Intraductal, Noninfiltrating (genetics)
• Carcinoma, Papillary (genetics)
• Estrogens (analysis, genetics)
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• Middle Aged
• Neoplasm Proteins (analysis, genetics)
• Oncogenes (genetics)
• Prognosis
• Proteins
• RNA, Messenger (genetics)
• Receptors, Estrogen (analysis, genetics)
• Retrospective Studies
• Survival Rate
• Transcription, Genetic
• Trefoil Factor-1
• Tumor Suppressor Proteins