Abstract | PURPOSE:
Hydrazine sulfate is a controversial agent that was originally studied in cancer patients approximately 20 years ago. Based on a series of recent trials that suggested that this drug might have utility in cancer patients, we conducted this study. PATIENTS AND METHODS: RESULTS: There were 127 assessable patients entered onto this clinical trial. Data from the study showed trends both for poorer survival and for poorer quality of life (QL) in the hydrazine group. There were no significant differences in the two study arms with regard to anorexia or weight loss. CONCLUSION:
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Authors | C L Loprinzi, S A Kuross, J R O'Fallon, D H Gesme Jr, J B Gerstner, R M Rospond, C D Cobau, R M Goldberg |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 12
Issue 6
Pg. 1121-5
(Jun 1994)
ISSN: 0732-183X [Print] United States |
PMID | 8201373
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Hydrazines
- hydrazine
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Topics |
- Aged
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Colorectal Neoplasms
(drug therapy, mortality, pathology)
- Double-Blind Method
- Female
- Humans
- Hydrazines
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Quality of Life
- Survival Rate
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