[Treatment of hypercholesterolemia with beta-pyridylcarbinol. Experiences after long term treatment over 8 years (author's transl)].

Abstract

78 patients with hypercholesterolemia were treated with beta-pyridylcarbinol from 1964 to 1966. In 1972 42 patients could be contacted again, 37 of them were reexamined. 14 of these 42 patients were still taking beta-pyridylcarbinol in 1972. Those who had taken more than 0.9 gm per day had a lower serum cholesterol level than in the beginning of the treatment in 1964. Clinical signs of atherosclerosis (angina pectoris and peripheral arterial disease) were significantly less in this group of patients. Besides a few flush reactions or heartburn no side effects to treatment were noted. The two groups of patients, with whom the 14 were compared, included 9 who had been taking clofibrate since 1966 and 19 patients without drug treatment for hypercholesterolemia. Both groups had higher serum cholesterol levels than the group of 14 with beta-pyridylcarbinol treatment over 8 years.

• Authors: N Zöllner, C Keller, G Wolfram
• Journal: Medizinische Klinik (Med Klin) Vol. 71 Issue 18 Pg. 768-74 (Apr 30 1976) ISSN: 0025-8458 [Print] Germany
• Vernacular Title: Behandlung der Hypercholesterinämie mit Beta-Pyridylcarbinol. IV. Erfahrungen nach acht Jahren Dauertherapie
• PMID: 818496 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Delayed-Action Preparations
• Pyridines
• Triglycerides
• Cholesterol
• Nicotinyl Alcohol
• Clofibrate

Topics

• Angina Pectoris (diagnosis)
• Cerebrovascular Disorders (diagnosis)
• Cholesterol (blood)
• Clofibrate (adverse effects, therapeutic use)
• Delayed-Action Preparations
• Follow-Up Studies
• Humans
• Hypercholesterolemia (blood, drug therapy)
• Intermittent Claudication
• Long-Term Care
• Nicotinyl Alcohol (adverse effects, therapeutic use)
• Pyridines (therapeutic use)
• Triglycerides (blood)