Effects of kami-kihi-to (jia-wei-gui-pi-tang) on autoantibodies in patients with chronic immune thrombocytopenic purpura.

Abstract

We studied the effect of Kami-kihi-to (Jia-Wei-Gui-Pi-Tang) on the production of autoantibodies in ten patients with chronic immune thrombocytopenic purpura. After administration of Kami-kihi-to, platelet count was increased in seven of the ten patients (p < 0.05). Using Western blotting, we demonstrated the disappearance of autoantibody reaction with antigen in one patient. However, platelet-associated IgG was decreased in eight of ten patients (p < 0.05). Kami-kihi-to appears to promote the suppression of autoantibodies in patients with chronic immune thrombocytopenic purpura. No side effects were observed in any patient. Thus, Kami-kihi-to may be a useful and safe drug in the management of chronic immune thrombocytopenia purpura.

• Authors: K Yamaguchi, H Kido, T Kawakatsu, T Fukuroi, M Suzuki, M Yanabu, S Nomura, T Kokawa, K Yasunaga
• Journal: The American journal of Chinese medicine (Am J Chin Med) Vol. 21 Issue 3-4 Pg. 251-5 ( 1993) ISSN: 0192-415X [Print] Singapore
• PMID: 8135169 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Drugs, Chinese Herbal
• Immunoglobulin G
• kamikihi-to

Topics

• Administration, Oral
• Adult
• Aged
• Autoantibodies (blood)
• Blood Platelets (immunology)
• Blotting, Western
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Humans
• Immunoglobulin G (blood)
• Male
• Middle Aged
• Platelet Count (drug effects)
• Purpura, Thrombocytopenic, Idiopathic (immunology, therapy)