Abstract |
The antiviral activity of Shigyaku-to (TJS-109), a traditional Chinese herbal medicine, was investigated in mice infected with herpes simplex virus type 1 (HSV-1). TJS-109 is a combination of the medicinal plant extracts from Zingiberis siccatum rhizoma, Aconiti tuber and Glycyrrhizae radix in a specific proportion. Mice infected with a 10 LD50 dose of HSV-1 were treated with TJS-109 orally at doses of 1.25 to 20 mg/kg 2 days before, and 1 and 4 days after the infection. The treated groups had 80% (1.25 mg/kg), 40% (5 mg/kg) and 23% (20 mg/kg) mortality rates 25 days after the infection as compared with a 100% mortality rate in control mice treated with saline. When HSV-1 infected mice (recipients) received CD8+ T cell fractions derived from spleens of mice treated with TJS-109 (donors), 70% of recipients survived, as compared with 0% survivors in the groups of mice treated with saline, B cell fractions, CD4+ T cell fractions or macrophage-enriched fractions prepared from the same donors. TJS-109 did not show any virucidal activities against HSV-1 or any virostatic activities on the growth of HSV-1 in Vero cells. These results suggest that TJS-109 protected mice exposed to lethal amounts of HSV-1 through the activation of CD8+ T cells.
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Authors | K Ikemoto, T Utsunomiya, M A Ball, M Kobayashi, R B Pollard, F Suzuki |
Journal | Experientia
(Experientia)
Vol. 50
Issue 5
Pg. 456-60
(May 15 1994)
ISSN: 0014-4754 [Print] Switzerland |
PMID | 7910798
(Publication Type: Journal Article)
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Chemical References |
- CD8 Antigens
- Drugs, Chinese Herbal
- shigyaku-to
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Topics |
- Animals
- CD4-Positive T-Lymphocytes
- CD8 Antigens
(immunology)
- Drugs, Chinese Herbal
(therapeutic use, toxicity)
- Herpes Simplex
(immunology, prevention & control, therapy)
- Herpesvirus 1, Human
(drug effects, growth & development)
- Immunotherapy, Adoptive
- Lymphocyte Transfusion
- Male
- Mice
- Mice, Inbred BALB C
- T-Lymphocyte Subsets
- Time Factors
- Vero Cells
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