Abstract | BACKGROUND: METHODS: RESULTS:
GR66234A and GR66235A show the same activity in reversing daunorubicin resistance and are more effective than verapamil. The difference in activity between verapamil and the enantiomers of teludipine is greater in ARNII cells than in MCF 7/R cells. Nevertheless, there are no significative differences in cellular daunorubicin accumulation between ARNII and MCF 7/R following exposure to teludipine, nor are there differences in intracellular daunorubicin distribution in the presence of either MDR reversing agent. CONCLUSIONS:
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Authors | M Tolomeo, R A Gancitano, M Musso, F Porretto, R Perricone, V Abbadessa, A Cajozzo |
Journal | Haematologica
(Haematologica)
1994 Jul-Aug
Vol. 79
Issue 4
Pg. 328-33
ISSN: 0390-6078 [Print] Italy |
PMID | 7806087
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calcium Channel Blockers
- Dihydropyridines
- teludipine
- Daunorubicin
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Topics |
- Animals
- Calcium Channel Blockers
(pharmacology)
- Daunorubicin
(pharmacology)
- Dihydropyridines
(pharmacology)
- Drug Resistance, Multiple
(genetics)
- Humans
- Mice
- Phenotype
- Stereoisomerism
- Tumor Cells, Cultured
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