[Disease-free survival of acute leukemia patients receiving autologous bone marrow transplant following intensive chemotherapy--a report of 11 cases].

Abstract

Eleven cases of acute leukemia patients were treated with autologous bone marrow transplantation (ABMT) following intensive chemotherapy with TACC protocol. Among them, eight were in first remission, three in second remission. The median age was 38 years (24-45 years). Bone marrow was purged in vitro before transplantation with procaine and hyperthermia in three cases with acute promyelocytic leukemia. In all patients, ABMT was successful. The results of treatment are as follows: as of May, 1994, the median remission and disease-free survival period was 31 months (6-57), seven cases have been in complete remission for 6-57 months (median 42 months) after treatment and are still alive. In four cases, ABMT was complicated by infection but it was controlled by antibiotics.

• Authors: X Xia, B Lin, D Wu
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 17 Issue 4 Pg. 307-10 (Jul 1995) ISSN: 0253-3766 [Print] China
• PMID: 7587904 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cytarabine
• Lomustine
• Cyclophosphamide
• Thioguanine

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bone Marrow Purging
• Bone Marrow Transplantation
• Cyclophosphamide (administration & dosage)
• Cytarabine (administration & dosage)
• Disease-Free Survival
• Female
• Humans
• Leukemia, Promyelocytic, Acute (therapy)
• Lomustine (administration & dosage)
• Male
• Middle Aged
• Thioguanine (administration & dosage)