Effects of arginine butyrate and tributyrylxylitol on cultured human sarcoma cells.

Abstract	The effects of arginine butyrate and tributyrylxylitol were studied comparatively in a human sarcoma cell line. Both induced important structural and functional modifications suggestive of cell differentiation, as shown by the dose-dependent increase of alkaline phosphatase activity and total protein content, at concentrations ranging from 1mM to 5 mM expressed in butyrate equivalents. hCG beta-subunit present in the culture medium increased with differentiation. Our results show that most of the differentiation changes previously reported for sodium butyrate in cancer cell lines are also produced by both drugs. Tributyrylxylitol appears to be the more potent and effective inducer of differentiation but its use is limited << in vitro >> on account of its relative toxicity at concentrations above 3 mM butyrate equivalents.
Authors	O Vincent-Fiquet, J C Rogez, F Boitte, M Brazier, G Desmet
Journal	Anticancer research (Anticancer Res) 1994 Sep-Oct Vol. 14 Issue 5A Pg. 1823-8 ISSN: 0250-7005 [Print] Greece
PMID	7531414 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents Butyrates Chorionic Gonadotropin Chorionic Gonadotropin, beta Subunit, Human Culture Media Macromolecular Substances Neoplasm Proteins Peptide Fragments tributyrylxylitol Arginine Alkaline Phosphatase arginine butyrate Xylitol
Topics	Alkaline Phosphatase (metabolism) Animals Antineoplastic Agents (pharmacology) Arginine (analogs & derivatives, pharmacology) Butyrates (pharmacology) Cell Differentiation (drug effects) Chorionic Gonadotropin (metabolism) Chorionic Gonadotropin, beta Subunit, Human Culture Media Humans Macromolecular Substances Mice Neoplasm Proteins (metabolism) Peptide Fragments (metabolism) Sarcoma (drug therapy, metabolism, pathology) Tumor Cells, Cultured (drug effects) Xylitol (analogs & derivatives, pharmacology)

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