Inhalation of racemic epinephrine in children with asthma. Dose-response relation and comparison with salbutamol.

Abstract

In this study the effects of nebulized racemic epinephrine (Micronephrine) were investigated in children with asthma. The drug was inhaled by a compressor nebulizer with a plastic mask. In the first part of the study it is shown that nebulized Micronephrine has a dose-dependent bronchodilatory effect. In the second part the effect is compared with that of nebulized salbutamol in 10 children (7-16 years of age) with bronchial asthma. The highest dose used in the dose-response trials (=0.9 mg Micronephrine/kg body-weight) was compared with 0.15 mg salbutamol/kg body-weight, which is the dose commonly used in Sweden. There was no significant difference between the drugs as regards increase of forced expiratory volume in 1 sec or duration of the increase. There was a small but significant increase in systolic blood pressure, measured 5 min after the inhalation of Micronephrine but no significant change in diastolic pressure or heart rate. Four children complained of temporary sore throat after the inhalation.

• Authors: B Kjellman, H Tollig, G Wettrell
• Journal: Allergy (Allergy) Vol. 35 Issue 7 Pg. 605-10 (Oct 1980) ISSN: 0105-4538 [Print] Denmark
• PMID: 7468946 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Racepinephrine
• Albuterol
• Epinephrine

Topics

• Acute Disease
• Administration, Intranasal
• Adolescent
• Albuterol (administration & dosage, adverse effects, therapeutic use)
• Asthma (drug therapy)
• Child
• Dose-Response Relationship, Drug
• Epinephrine (administration & dosage, adverse effects, therapeutic use)
• Forced Expiratory Volume
• Humans
• Racepinephrine