Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.

Abstract

A number of N-acyl and N-(alkoxycarbonyl)-5-fluorouracil derivatives possessing, for example, benzoyl, o-toluyl, acetyl, propionyl, heptanoyl, ethoxycarbonyl, phenoxycarbonyl, and benzyloxycarbonyl groups as N1 and/or N3 substituents were synthesized, and their antitumor activities were evaluated. The synthesis was achieved by a direct and two-step acylation of 5-fluorouracil and by selective N1-deacetylation of N1-acetyl-N3-substituted-5-fluorouracil under appropriate reaction conditions. Several N3-benzoyl- and N3-o-toluyl-5-fluorouracil derivates and showed significant activity against experimental tumor, and N1-acetyl-N3-o-toluyl-5-fluorouracil was found to be most promising among them. Further investigation revealed 12 to retain higher activity toward various tumors, with lower toxicity and good blood level, than either 1 or FT-207, even for oral administration.

• Authors: T Kametani, K Kigasawa, M Hiiragi, K Wakisaka, S Haga, Y Nagamatsu, H Sugi, K Fukawa, O Irino, T Yamamoto, N Nishimura, A Taguchi, T Okada, M Nakayama
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 23 Issue 12 Pg. 1324-9 (Dec 1980) ISSN: 0022-2623 [Print] United States
• PMID: 7452684 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Fluorouracil

Topics

• Animals
• Antineoplastic Agents (chemical synthesis)
• Chemical Phenomena
• Chemistry
• Female
• Fluorouracil (analogs & derivatives, chemical synthesis, pharmacology)
• Lethal Dose 50
• Leukemia P388 (drug therapy)
• Mice
• Neoplasms, Experimental (drug therapy)