Sister-chromatid exchanges and chromosomal aberrations in cultured Chinese hamster cells treated with pesticides positive in microbial reversion assays.

Abstract

The induction of sister-chromatid exchanges (SCEs), chromosomal aberrations and polyploids was investigated in cultured Chinese hamster cells treated with pesticides or a related compound positive in microbial reversion assays. The chemicals tested were captan, captafol, 1,2-dibromoethane (EDB), 1,2-dibromo-3-chloropropane (DBCP), 5-nitro-1-naphrhonitrile (NNN), p-dimethylaminobenzenediazo sodium sulfonate (DAPA), 2-hydrazinoethanol (HEH), vamidothion, dichlorovos (DDVP), N-nitroso-ethylenethiourea (N-nitroso-ETU), and 2,4-dinitrophenyl thiocyanate (NBT). A significant and dose-dependent increase in the frequency of SCEs and chromosomal aberrations was observed in the cell cultures treated with captan, captafol, EDB, DBCP, HEH, DDVP, vamidothion, DAPA or N-nitroso-ETU or NBT produced a significant increase in the frequency of polyploid cells, whereas the other agents did not. When compared with results from microbial reversion assays, a close correlation was observed between the ability to induce SCEs or chromosomal aberrations and the mutagenic potency in bacteria (r:0.71-0.84).

• Authors: H Tezuka, N Ando, R Suzuki, M Terahata, M Moriya, Y Shirasu
• Journal: Mutation research (Mutat Res) Vol. 78 Issue 2 Pg. 177-91 (Jun 1980) ISSN: 0027-5107 [Print] Netherlands
• PMID: 7393245 (Publication Type: Journal Article)

Chemical References

• Carcinogens
• Mutagens
• Pesticides
• Captan

Topics

• Aneuploidy
• Animals
• Captan (pharmacology)
• Carcinogens (pharmacology)
• Cell Line
• Chromosome Aberrations
• Chromosomes (drug effects)
• Cricetinae
• Cricetulus
• Crossing Over, Genetic
• Lung
• Mutagens
• Pesticides (pharmacology)
• Sister Chromatid Exchange