Effect of iodoxamide ethyl on allergy skin tests.

Abstract

Lodoxamide ethyl is a new cromolyn-like drug which prevents antigen-induced mediator release from mast cells and antigen-induced bronchoconstriction in sensitive animals and man. The purpose of this study was to determine the effect of a single administration of lodoxamide ethyl on allergy skin tests. The effect of this drug on allergy skin testing was studied in a double-blind design on ten adult subjects allergic to ragweed. Serial end-point titrations with short ragweed extract and with histamine were performed after a placebo and 1- and 3-mg capsules of lodoxamide ethyl. The immediate wheal-and-flare responses as well as the late allergic reaction were recorded. No statistically significant difference was found between lodoxamide ethyl and placebo in the suppression of the allergen-induced immediate wheal-and-flare response or the late allergic reaction. Furthermore, 1 and 3 mg of oral lodoxamide ethyl did not inhibit the histamine-induced cutaneous reactions.

• Authors: E Frigas, C E Reed
• Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 65 Issue 4 Pg. 257-62 (Apr 1980) ISSN: 0091-6749 [Print] United States
• PMID: 7358942 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Amino Acids
• Oxamic Acid
• lodoxamide ethyl

Topics

• Amino Acids (pharmacology)
• Dose-Response Relationship, Drug
• Humans
• Hypersensitivity (diagnosis)
• Male
• Oxamic Acid (administration & dosage, adverse effects, analogs & derivatives, pharmacology)
• Skin Tests