Abstract |
Correlations between lymphocyte aryl hydrocarbon hydroxylase ( AHH) inducibility in cord blood and maternal lymphocytes and placental AHH activity were studied in 15 smokers and 11 non-smokers. Placental AHH activity was extremely low in the non-smokers regardless of the lymphocyte AHH induction ratio, but was elevated to a variable extent in the smokers, in whom it showed a statistically significant correlation (r = 0.75, P less than 0.01) with cord blood lymphocyte AHH inducibility. The correlation between maternal lymphocyte AHH inducibility and placental AHH activity was poor (r = 0.04, not significant). These findings suggest that AHH induction in man may be 'systematically' regulated and that the genetic background will determine the extent of induction at a given level of exposure to polycyclic aromatic hydrocarbons.
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Authors | O Pelkonen, N T Karki, R Tuimala |
Journal | Cancer letters
(Cancer Lett)
Vol. 13
Issue 2
Pg. 103-10
(Jul 1981)
ISSN: 0304-3835 [Print] Ireland |
PMID | 7332631
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aryl Hydrocarbon Hydroxylases
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Topics |
- Adolescent
- Adult
- Aryl Hydrocarbon Hydroxylases
(biosynthesis)
- Enzyme Induction
- Female
- Fetal Blood
(cytology)
- Humans
- Lymphocytes
(enzymology)
- Placenta
(enzymology)
- Pregnancy
- Tobacco Use Disorder
(enzymology)
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