Clinical trials of broad spectrum anthelmintics against soil-transmitted helminthiasis.

Abstract

Clinical trials on the three broad spectrum anthelmintics against trichuriasis, ascariasis and hookworm infection were carried out in a rural community in Irosin, Sorsogon. Flubendazole (Fluvermal) appears to be a promising drug against trichuriasis particularly when periodic mass treatment of a community is carried out. Mebendazole (Antiox) also appears to be promising given as single dose during mass treatment of soil-transmitted helminthiasis. As shown in previous studies, oxantel-pyrantel (Quantrel) should be given at 15 mg/kg body weight at 12-hour intervals or 20 mg/kg body weight single dose rather than 10 mg/kg body weight in a single dose when treating trichuriasis.

• Authors: B D Cabrera, E V Valdez, T G Go
• Journal: The Southeast Asian journal of tropical medicine and public health (Southeast Asian J Trop Med Public Health) Vol. 11 Issue 4 Pg. 502-6 (Dec 1980) ISSN: 0125-1562 [Print] Thailand
• PMID: 7221692 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anthelmintics
• Drug Combinations
• Soil
• quantrel
• Pyrantel
• Mebendazole
• flubendazole

Topics

• Anthelmintics (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Combinations (therapeutic use)
• Drug Evaluation
• Feces (parasitology)
• Humans
• Mebendazole (analogs & derivatives, therapeutic use)
• Philippines
• Pyrantel (analogs & derivatives, therapeutic use)
• Soil
• Trichuriasis (drug therapy)