Abstract |
The majority of sera from myasthenic patients cannot precipitate all available receptor-toxin complex even in conditions of a 4,000-fold excess of antibody. This effect was traced to displacement of toxin from the receptor-toxin complex. Pure IgG prepared from the serum of a myasthenic patient was as effective as the original serum in displacing ability. The possible effect of such antibodies on the correlation of antibody titre and disease state is discussed.
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Authors | T Barkas, J A Simpson |
Journal | Journal of clinical & laboratory immunology
(J Clin Lab Immunol)
Vol. 9
Issue 2
Pg. 113-7
(Nov 1982)
ISSN: 0141-2760 [Print] Scotland |
PMID | 7154056
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Bungarotoxins
- Immunoglobulin G
- Receptors, Cholinergic
- Receptors, Nicotinic
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Topics |
- Antibody Specificity
- Autoantibodies
(immunology)
- Binding, Competitive
- Bungarotoxins
(metabolism)
- Humans
- Immunoglobulin G
(immunology)
- Myasthenia Gravis
(immunology)
- Receptors, Cholinergic
(immunology)
- Receptors, Nicotinic
(immunology, metabolism)
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